Travel light: Essential packing for membrane proteins with an active lifestyle

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We review the considerable progress during the recent decade in the endeavours of designing, optimising, and utilising carrier particle systems for structural and functional studies of membrane proteins in near-native environments. New and improved systems are constantly emerging, novel studies push the perceived limits of a given carrier system, and specific carrier systems consolidate and entrench themselves as the system of choice for particular classes of target membrane protein systems. This review covers the most frequently used carrier systems for such studies and emphasises similarities and differences between these systems as well as current trends and future directions for the field. Particular interest is devoted to the biophysical properties and membrane mimicking ability of each system and the manner in which this may impact an embedded membrane protein and an eventual structural or functional study.

OriginalsprogEngelsk
TidsskriftBiochimie
Vol/bind205
Sider (fra-til)3-26
Antal sider24
ISSN0300-9084
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
We thank the Villum Foundation (project numbers 35955 and 40960 ) and the Lundbeck Foundation (project number R155-2015-2666 ) for financial support.

Publisher Copyright:
© 2022 The Authors

ID: 339633955