Curvature strains as a global orchestrator of morphogenesis

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Successful morphogenesis on the scale of organs or organisms requires strict coordination between the constituent cells whose action on the local scale must be orchestrated accurately to achieve a functional shape on the global scale. We present a theoretical model in which morphogenetic information is encoded only through a locally preferred curvature, but with cell dynamics which simultaneously ensures that these interactions globally achieve morphogenesis and correct cell-neighbor exchanges to avoid cell stretches. This is achieved by a cell-cell interaction potential that drives correct cell intercalation to reorganize the cell sheet dynamically during the deformation processes. We demonstrate morphogenesis of simple three-dimensional shapes and study the effects of fixed cell neighbor connectivity and noisy cell division.

Original languageEnglish
Article number023171
JournalPhysical Review Research
Volume4
Issue number2
Number of pages10
ISSN2643-1564
DOIs
Publication statusPublished - 31 May 2022

    Research areas

  • CONVERGENT EXTENSION, CELL-MIGRATION, MODEL, MECHANICS, SHAPE, GASTRULATION, SIMULATION, EPITHELIA, INSIGHTS, BEHAVIOR

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