Activity-induced instabilities of brain organoids

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We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.

Original languageEnglish
Article number147
JournalThe European Physical Journal E: Soft Matter and Biological Physics
Volume44
Issue number12
Number of pages8
ISSN1292-8941
DOIs
Publication statusPublished - 7 Dec 2021

    Research areas

  • REVEAL, GELS

ID: 286991680