Bifractal nature of chromosome contact maps

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Modern biological techniques such as Hi-C permit one to measure probabilities that different chromosomal regions are close in space. These probabilities can be visualized as matrices called contact maps. In this paper, we introduce a multifractal analysis of chromosomal contact maps. Our analysis reveals that Hi-C maps are bifractal, i.e., complex geometrical objects characterized by two distinct fractal dimensions. To rationalize this observation, we introduce a model that describes chromosomes as a hierarchical set of nested domains and we solve it exactly. The predicted multifractal spectrum is in excellent quantitative agreement with experimental data. Moreover, we show that our theory yields a more robust estimation of the scaling exponent of the contact probability than existing methods. By applying this method to experimental data, we detect subtle conformational changes among chromosomes during differentiation of human stem cells.

Original languageEnglish
Article number043078
JournalPhysical Review Research
Volume2
Issue number4
Number of pages9
DOIs
Publication statusPublished - 15 Oct 2020

    Research areas

  • 3D GENOME, DOMAINS, ORGANIZATION, PRINCIPLES, FLUCTUATIONS, CONFORMATION, ACTIVATION, INSULATION, SCALE

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