Physics of liquid crystals in cell biology

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The past decade has witnessed a rapid growth in understanding of the pivotal roles of mechanical stresses and physical forces in cell biology. As a result, an integrated view of cell biology is evolving, where genetic and molecular features are scrutinised hand in hand with physical and mechanical characteristics of cells. Physics of liquid crystals has emerged as a burgeoning new frontier in cell biology over the past few years, fuelled by an increasing identification of orientational order and topological defects in cell biology, spanning scales from subcellular filaments to individual cells and multicellular tissues. Here, we provide an account of the most recent findings and developments, together with future promises and challenges in this rapidly evolving interdisciplinary research direction.

Original languageEnglish
JournalTrends in Cell Biology
Volume32
Issue number2
Pages (from-to)140-150
Number of pages11
ISSN0962-8924
DOIs
Publication statusPublished - Feb 2022

Bibliographical note

Funding Information:
We acknowledge support from the Novo Nordisk Foundation (grant no. NNF18SA0035142), Villum Fonden (grant no. 29476), funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 847523 (INTERACTIONS), the LABEX Who Am I? (ANR-11-LABX-0071), the Ligue Contre le Cancer (Equipe labellisée 2019), and the Agence Nationale de la Recherche (‘POLCAM’ ANR-17-CE13-0013 and ‘MyoFuse’ ANR-19-CE13-0016). We thank Julia Yeomans, Thuan Beng Saw, and the group members from the ‘Cell adhesion and migration’ team and from the ‘Active & intelligent matter’ group for helpful discussions.

Funding Information:
We acknowledge support from the Novo Nordisk Foundation (grant no. NNF18SA0035142), Villum Fonden (grant no. 29476), funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 847523 (INTERACTIONS), the LABEX Who Am I? (ANR-11-LABX-0071), the Ligue Contre le Cancer (Equipe labellis?e 2019), and the Agence Nationale de la Recherche (?POLCAM? ANR-17-CE13-0013 and ?MyoFuse? ANR-19-CE13-0016). We thank Julia Yeomans, Thuan Beng Saw, and the group members from the ?Cell adhesion and migration? team and from the ?Active & intelligent matter? group for helpful discussions.

Publisher Copyright:
© 2021 Elsevier Ltd

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