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Ulrich F. Keyser

University of Cambridge.

Title: DNA (origami) nanopores

Abstract: DNA nanotechnology has enabled the construction of DNA origami nanopores [1]. These synthetic designer nanopores promise improved capabilities for enhanced single molecule detection. Here, we will review the recent developments of DNA origami nanopores in lipid membranes [2]. These structures have extraordinary versatility and are a new and powerful tool in nanobiotechnology for a wide range of important applications. In this talk I will discuss the recent realisation of ion channel entirely made from DNA [3,4]. The versatility of the DNA nanotechnology enables the creation of designer nanopores as model systems for protein channels from channels to porins spanning several orders of magnitude in conductance and molecular weight [4].

[1] Bell, et al. DNA origami nanopores. Nano Letters, 12(1):512-517, 2012
[2] Burns, et al., Angewandte Chemie , 52(46):12069-12072, 2013
[3] Goepfrich, et al. Nano Letters, 15(5):3134-3138, 2015
[4] Goepfrich, et al. submitted, 2016

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