Activity-induced instabilities of brain organoids
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Activity-induced instabilities of brain organoids. / Thijssen, Kristian; Kusters, Guido L. A.; Doostmohammadi, Amin.
I: The European Physical Journal E: Soft Matter and Biological Physics, Bind 44, Nr. 12, 147, 07.12.2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Activity-induced instabilities of brain organoids
AU - Thijssen, Kristian
AU - Kusters, Guido L. A.
AU - Doostmohammadi, Amin
PY - 2021/12/7
Y1 - 2021/12/7
N2 - We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
AB - We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
KW - REVEAL
KW - GELS
U2 - 10.1140/epje/s10189-021-00149-z
DO - 10.1140/epje/s10189-021-00149-z
M3 - Journal article
C2 - 34874504
VL - 44
JO - European Physical Journal E
JF - European Physical Journal E
SN - 1292-8941
IS - 12
M1 - 147
ER -
ID: 286991680