Bridging microscopic cell dynamics to nematohydrodynamics of cell monolayers
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Bridging microscopic cell dynamics to nematohydrodynamics of cell monolayers. / Ardaseva, Aleksandra; Mueller, Romain; Doostmohammadi, Amin.
I: Soft Matter, Bind 18, Nr. 25, 29.06.2022, s. 4737-4746.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Bridging microscopic cell dynamics to nematohydrodynamics of cell monolayers
AU - Ardaseva, Aleksandra
AU - Mueller, Romain
AU - Doostmohammadi, Amin
PY - 2022/6/29
Y1 - 2022/6/29
N2 - It is increasingly being realized that liquid-crystalline features can play an important role in the properties and dynamics of cell monolayers. Here, we present a cell-based model of cell layers, based on the phase-field formulation, that connects cell-cell interactions specified at the single cell level to large-scale nematic and hydrodynamic properties of the tissue. In particular, we present a minimal formulation that reproduces the well-known bend and splay hydrodynamic instabilities of the continuum nemato-hydrodynamic formulation of active matter, together with an analytical description of the instability threshold in terms of activity and elasticity of the cells. Furthermore, we provide a quantitative characterisation and comparison of flows and topological defects for extensile and contractile stress generation mechanisms, and demonstrate activity-induced heterogeneity and spontaneous formation of gaps within a confluent monolayer. Together, these results contribute to bridging the gap between cell-scale dynamics and tissue-scale collective cellular organisation.
AB - It is increasingly being realized that liquid-crystalline features can play an important role in the properties and dynamics of cell monolayers. Here, we present a cell-based model of cell layers, based on the phase-field formulation, that connects cell-cell interactions specified at the single cell level to large-scale nematic and hydrodynamic properties of the tissue. In particular, we present a minimal formulation that reproduces the well-known bend and splay hydrodynamic instabilities of the continuum nemato-hydrodynamic formulation of active matter, together with an analytical description of the instability threshold in terms of activity and elasticity of the cells. Furthermore, we provide a quantitative characterisation and comparison of flows and topological defects for extensile and contractile stress generation mechanisms, and demonstrate activity-induced heterogeneity and spontaneous formation of gaps within a confluent monolayer. Together, these results contribute to bridging the gap between cell-scale dynamics and tissue-scale collective cellular organisation.
KW - TOPOLOGICAL DEFECTS
KW - FORCES
KW - MECHANISM
U2 - 10.1039/d2sm00537a
DO - 10.1039/d2sm00537a
M3 - Journal article
C2 - 35703313
VL - 18
SP - 4737
EP - 4746
JO - Soft Matter
JF - Soft Matter
SN - 1744-683X
IS - 25
ER -
ID: 315529777