Curvature strains as a global orchestrator of morphogenesis
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Curvature strains as a global orchestrator of morphogenesis. / Kirkegaard, Julius B.
I: Physical Review Research, Bind 4, Nr. 2, 023171, 31.05.2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Curvature strains as a global orchestrator of morphogenesis
AU - Kirkegaard, Julius B.
PY - 2022/5/31
Y1 - 2022/5/31
N2 - Successful morphogenesis on the scale of organs or organisms requires strict coordination between the constituent cells whose action on the local scale must be orchestrated accurately to achieve a functional shape on the global scale. We present a theoretical model in which morphogenetic information is encoded only through a locally preferred curvature, but with cell dynamics which simultaneously ensures that these interactions globally achieve morphogenesis and correct cell-neighbor exchanges to avoid cell stretches. This is achieved by a cell-cell interaction potential that drives correct cell intercalation to reorganize the cell sheet dynamically during the deformation processes. We demonstrate morphogenesis of simple three-dimensional shapes and study the effects of fixed cell neighbor connectivity and noisy cell division.
AB - Successful morphogenesis on the scale of organs or organisms requires strict coordination between the constituent cells whose action on the local scale must be orchestrated accurately to achieve a functional shape on the global scale. We present a theoretical model in which morphogenetic information is encoded only through a locally preferred curvature, but with cell dynamics which simultaneously ensures that these interactions globally achieve morphogenesis and correct cell-neighbor exchanges to avoid cell stretches. This is achieved by a cell-cell interaction potential that drives correct cell intercalation to reorganize the cell sheet dynamically during the deformation processes. We demonstrate morphogenesis of simple three-dimensional shapes and study the effects of fixed cell neighbor connectivity and noisy cell division.
KW - CONVERGENT EXTENSION
KW - CELL-MIGRATION
KW - MODEL
KW - MECHANICS
KW - SHAPE
KW - GASTRULATION
KW - SIMULATION
KW - EPITHELIA
KW - INSIGHTS
KW - BEHAVIOR
U2 - 10.1103/PhysRevResearch.4.023171
DO - 10.1103/PhysRevResearch.4.023171
M3 - Journal article
VL - 4
JO - Physical Review Research
JF - Physical Review Research
SN - 2643-1564
IS - 2
M1 - 023171
ER -
ID: 315473779