Dominant negative autoregulation limits steady-state repression levels in gene networks
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Dominant negative autoregulation limits steady-state repression levels in gene networks. / Semsey, Szabolcs; Krishna, Sandeep; Erdossy, János; Horváth, Péter; Orosz, László; Sneppen, Kim; Adhya, Sankar.
I: Journal of Bacteriology, Bind 191, Nr. 14, 07.2009, s. 4487-91.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Dominant negative autoregulation limits steady-state repression levels in gene networks
AU - Semsey, Szabolcs
AU - Krishna, Sandeep
AU - Erdossy, János
AU - Horváth, Péter
AU - Orosz, László
AU - Sneppen, Kim
AU - Adhya, Sankar
PY - 2009/7
Y1 - 2009/7
N2 - Many transcription factors repress transcription of their own genes. Negative autoregulation has been shown to reduce cell-cell variation in regulatory protein levels and speed up the response time in gene networks. In this work we examined transcription regulation of the galS gene and the function of its product, the GalS protein. We observed a unique operator preference of the GalS protein characterized by dominant negative autoregulation. We show that this pattern of regulation limits the repression level of the target genes in steady states. We suggest that transcription factors with dominant negative autoregulation are designed for regulating gene expression during environmental transitions.
AB - Many transcription factors repress transcription of their own genes. Negative autoregulation has been shown to reduce cell-cell variation in regulatory protein levels and speed up the response time in gene networks. In this work we examined transcription regulation of the galS gene and the function of its product, the GalS protein. We observed a unique operator preference of the GalS protein characterized by dominant negative autoregulation. We show that this pattern of regulation limits the repression level of the target genes in steady states. We suggest that transcription factors with dominant negative autoregulation are designed for regulating gene expression during environmental transitions.
KW - Escherichia coli
KW - Escherichia coli Proteins
KW - Gene Expression Regulation
KW - Gene Regulatory Networks
KW - Homeostasis
KW - Repressor Proteins
KW - Journal Article
KW - Research Support, N.I.H., Intramural
KW - Research Support, Non-U.S. Gov't
U2 - 10.1128/JB.00056-09
DO - 10.1128/JB.00056-09
M3 - Journal article
C2 - 19429616
VL - 191
SP - 4487
EP - 4491
JO - Journal of Bacteriology
JF - Journal of Bacteriology
SN - 0021-9193
IS - 14
ER -
ID: 163917399