Simulating realistic membrane shapes
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Simulating realistic membrane shapes. / Pezeshkian, Weria; Marrink, Siewert J.
I: Current Opinion in Cell Biology, Bind 71, 01.08.2021, s. 103-111.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Simulating realistic membrane shapes
AU - Pezeshkian, Weria
AU - Marrink, Siewert J.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. These two central features of biomembranes have been the subject of numerous simulation studies, using a diverse range of computational techniques. Currently, the field is able to capture this complexity at increasing levels of realism and connect the microscopic view on protein-lipid interactions to cellular morphologies at the level of entire organelles. Here we highlight recent advances in this topic, identify current bottlenecks, and sketch possible ways ahead.
AB - Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. These two central features of biomembranes have been the subject of numerous simulation studies, using a diverse range of computational techniques. Currently, the field is able to capture this complexity at increasing levels of realism and connect the microscopic view on protein-lipid interactions to cellular morphologies at the level of entire organelles. Here we highlight recent advances in this topic, identify current bottlenecks, and sketch possible ways ahead.
KW - Membrane curvature
KW - Multiscale simulations
KW - Organelle shape
KW - Mesoscale models
KW - Molecular dynamics
KW - Cell membranes
KW - CURVATURE
KW - PARTICLES
U2 - 10.1016/j.ceb.2021.02.009
DO - 10.1016/j.ceb.2021.02.009
M3 - Review
C2 - 33721706
VL - 71
SP - 103
EP - 111
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
ER -
ID: 316749814