Why do phage play dice?
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Why do phage play dice? / Avlund, Mikkel; Dodd, Ian B; Semsey, Szabolcs; Sneppen, Kim; Krishna, Sandeep.
I: Journal of Virology, Bind 83, Nr. 22, 11.2009, s. 11416-20.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Why do phage play dice?
AU - Avlund, Mikkel
AU - Dodd, Ian B
AU - Semsey, Szabolcs
AU - Sneppen, Kim
AU - Krishna, Sandeep
PY - 2009/11
Y1 - 2009/11
N2 - Phage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a "game" of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage.
AB - Phage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a "game" of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage.
KW - Bacteriophage lambda
KW - Game Theory
KW - Lysogeny
KW - Probability
KW - Stochastic Processes
KW - Virus Activation
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1128/JVI.01057-09
DO - 10.1128/JVI.01057-09
M3 - Journal article
C2 - 19740995
VL - 83
SP - 11416
EP - 11420
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 22
ER -
ID: 163917171