Cell-penetrating peptides for drug delivery across membrane barriers
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Cell-penetrating peptides for drug delivery across membrane barriers. / Foged, Camilla; Nielsen, Hanne Moerck.
In: Expert Opinion on Drug Delivery, Vol. 5, No. 1, 2008, p. 105-17.Research output: Contribution to journal › Review › Research
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TY - JOUR
T1 - Cell-penetrating peptides for drug delivery across membrane barriers
AU - Foged, Camilla
AU - Nielsen, Hanne Moerck
PY - 2008
Y1 - 2008
N2 - During the last decade, cell-penetrating peptides have been investigated for their ability to overcome the plasma membrane barrier of mammalian cells for the intracellular or transcellular delivery of cargoes as diverse as low molecular weight drugs, imaging agents, oligonucleotides, peptides, proteins and colloidal carriers such as liposomes and polymeric nanoparticles. Their ability to cross biological membranes in a non-disruptive way without apparent toxicity is highly desired for increasing drug bioavailability. This review provides an overview of the application of cell-penetrating peptides as transmembrane drug delivery agents, according to the recent literature, and discusses critical issues and future challenges in relation to fully understanding the fundamental principles of the cell-penetrating peptide-mediated membrane translocation of cargoes and the exploitation of their therapeutic potential.
AB - During the last decade, cell-penetrating peptides have been investigated for their ability to overcome the plasma membrane barrier of mammalian cells for the intracellular or transcellular delivery of cargoes as diverse as low molecular weight drugs, imaging agents, oligonucleotides, peptides, proteins and colloidal carriers such as liposomes and polymeric nanoparticles. Their ability to cross biological membranes in a non-disruptive way without apparent toxicity is highly desired for increasing drug bioavailability. This review provides an overview of the application of cell-penetrating peptides as transmembrane drug delivery agents, according to the recent literature, and discusses critical issues and future challenges in relation to fully understanding the fundamental principles of the cell-penetrating peptide-mediated membrane translocation of cargoes and the exploitation of their therapeutic potential.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1517/17425247.5.1.105
DO - 10.1517/17425247.5.1.105
M3 - Review
C2 - 18095931
VL - 5
SP - 105
EP - 117
JO - Expert Opinion on Drug Delivery
JF - Expert Opinion on Drug Delivery
SN - 1742-5247
IS - 1
ER -
ID: 2967715