Comparisons of estimated intakes and plasma concentrations of selected fatty acids in pregnancy
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Comparisons of estimated intakes and plasma concentrations of selected fatty acids in pregnancy. / Madsen, Marie Terese Barlebo; Bjerregaard, Anne Ahrendt; Furtado, Jeremy D; Halldorsson, Thorhallur Ingi; Strøm, Marin; Granström, Charlotta; Giovannucci, Edward; Olsen, Sjurdur F.
In: Nutrients, Vol. 11, No. 3, 568, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparisons of estimated intakes and plasma concentrations of selected fatty acids in pregnancy
AU - Madsen, Marie Terese Barlebo
AU - Bjerregaard, Anne Ahrendt
AU - Furtado, Jeremy D
AU - Halldorsson, Thorhallur Ingi
AU - Strøm, Marin
AU - Granström, Charlotta
AU - Giovannucci, Edward
AU - Olsen, Sjurdur F
N1 - (Ekstern)
PY - 2019
Y1 - 2019
N2 - The growing interest in potential health effects of long-chain polyunsaturated fatty acids (PUFAs) makes it important to evaluate the method used to assess the fatty acid intake in nutrition research studies. We aimed to validate the questionnaire-based dietary intake of selected PUFAs: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), α-linolenic acid (ALA), linoleic acid (LA), and arachidonic acid (AA) within the Danish National Birth Cohort (DNBC), by comparing 345 women's reported intake with concentration of plasma biomarkers. The applied questionnaire- and biomarker data reflect dietary intake from around the same time point in mid-pregnancy and relationships were investigated by use of Pearson and Spearman correlation and linear regression statistics. We demonstrated moderate but consistent adjusted correlations between dietary intake estimates and the corresponding plasma biomarker concentrations (differences in plasma concentration per 100 mg/day greater intake of 0.05 (95% CI: 0.02; 0.08)) and 0.05 (95% CI: 0.01; 0.08) percentage of total plasma fatty acids for EPA and DHA, respectively). The associations strengthened when restricting the analyses to women with ALA intake below the median intake. We found a weak correlation between the dietary intake of ALA and its plasma biomarker with a difference in plasma concentration of 0.07 (95% CI: 0.03; 0.10) percent of total plasma fatty acids per 1 g/day greater intake, while the dietary intake of LA and AA did not correlate with their corresponding biomarkers.
AB - The growing interest in potential health effects of long-chain polyunsaturated fatty acids (PUFAs) makes it important to evaluate the method used to assess the fatty acid intake in nutrition research studies. We aimed to validate the questionnaire-based dietary intake of selected PUFAs: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), α-linolenic acid (ALA), linoleic acid (LA), and arachidonic acid (AA) within the Danish National Birth Cohort (DNBC), by comparing 345 women's reported intake with concentration of plasma biomarkers. The applied questionnaire- and biomarker data reflect dietary intake from around the same time point in mid-pregnancy and relationships were investigated by use of Pearson and Spearman correlation and linear regression statistics. We demonstrated moderate but consistent adjusted correlations between dietary intake estimates and the corresponding plasma biomarker concentrations (differences in plasma concentration per 100 mg/day greater intake of 0.05 (95% CI: 0.02; 0.08)) and 0.05 (95% CI: 0.01; 0.08) percentage of total plasma fatty acids for EPA and DHA, respectively). The associations strengthened when restricting the analyses to women with ALA intake below the median intake. We found a weak correlation between the dietary intake of ALA and its plasma biomarker with a difference in plasma concentration of 0.07 (95% CI: 0.03; 0.10) percent of total plasma fatty acids per 1 g/day greater intake, while the dietary intake of LA and AA did not correlate with their corresponding biomarkers.
KW - Faculty of Science
KW - Long-chained n-3 fatty acids
KW - LCn3FAs
KW - Polyunsaturated fatty acid
KW - PUFAs
KW - Food frequency questionnaire
KW - FFQ
KW - Validation study
KW - Biomarkers
KW - Danish National Birth Cohort
KW - Pregnancy diet
U2 - 10.3390/nu11030568
DO - 10.3390/nu11030568
M3 - Journal article
C2 - 30845776
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 3
M1 - 568
ER -
ID: 226874509