Deconstructing the principles of ductal network formation in the pancreas
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Deconstructing the principles of ductal network formation in the pancreas. / Dahl-Jensen, Svend Bertel; Yennek, Siham; Flasse, Lydie; Larsen, Hjalte List; Sever, Dror; Karremore, Gopal; Novak, Ivana; Sneppen, Kim; Botton, Anne.
In: PLOS Biology, Vol. 16, No. 7, e2002842, 2018.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Deconstructing the principles of ductal network formation in the pancreas
AU - Dahl-Jensen, Svend Bertel
AU - Yennek, Siham
AU - Flasse, Lydie
AU - Larsen, Hjalte List
AU - Sever, Dror
AU - Karremore, Gopal
AU - Novak, Ivana
AU - Sneppen, Kim
AU - Botton, Anne
PY - 2018
Y1 - 2018
N2 - The mammalian pancreas is a branched organ that does not exhibit stereotypic branching patterns, similarly to most other glands. Inside branches, it contains a network of ducts that undergo a transition from unconnected microlumen to a mesh of interconnected ducts and finally to a treelike structure. This ductal remodeling is poorly understood, both on a microscopic and macroscopic level. In this article, we quantify the network properties at different developmental stages. We find that the pancreatic network exhibits stereotypic traits at each stage and that the network properties change with time toward the most economical and optimized delivery of exocrine products into the duodenum. Using in silico modeling, we show how steps of pancreatic network development can be deconstructed into two simple rules likely to be conserved for many other glands. The early stage of the network is explained by noisy, redundant duct connection as new microlumens form. The later transition is attributed to pruning of the network based on the flux of fluid running through the pancreatic network into the duodenum.
AB - The mammalian pancreas is a branched organ that does not exhibit stereotypic branching patterns, similarly to most other glands. Inside branches, it contains a network of ducts that undergo a transition from unconnected microlumen to a mesh of interconnected ducts and finally to a treelike structure. This ductal remodeling is poorly understood, both on a microscopic and macroscopic level. In this article, we quantify the network properties at different developmental stages. We find that the pancreatic network exhibits stereotypic traits at each stage and that the network properties change with time toward the most economical and optimized delivery of exocrine products into the duodenum. Using in silico modeling, we show how steps of pancreatic network development can be deconstructed into two simple rules likely to be conserved for many other glands. The early stage of the network is explained by noisy, redundant duct connection as new microlumens form. The later transition is attributed to pruning of the network based on the flux of fluid running through the pancreatic network into the duodenum.
U2 - 10.1371/journal.pbio.2002842
DO - 10.1371/journal.pbio.2002842
M3 - Journal article
C2 - 30048442
VL - 16
JO - PLoS Biology
JF - PLoS Biology
SN - 1544-9173
IS - 7
M1 - e2002842
ER -
ID: 201609286