Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults
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Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults. / Tranæs, Kaare; Ding, Cherlyn; Chooi, Yu Chung; Chan, Zhiling; Choo, John; Leow, Melvin K-S; Magkos, Faidon.
In: Frontiers in Nutrition, Vol. 8, 651199, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults
AU - Tranæs, Kaare
AU - Ding, Cherlyn
AU - Chooi, Yu Chung
AU - Chan, Zhiling
AU - Choo, John
AU - Leow, Melvin K-S
AU - Magkos, Faidon
N1 - Copyright © 2021 Tranæs, Ding, Chooi, Chan, Choo, Leow and Magkos.
PY - 2021
Y1 - 2021
N2 - Insulin resistance in obesity coincides with abnormalities in lipid profile and lipoprotein subclass distribution and size even before abnormalities in glucose homeostasis manifest. We aimed to assess this relationship in the absence of obesity. Insulin sensitivity (3-h intravenous glucose tolerance test and minimal modeling) and lipoprotein particle concentrations and sizes (proton nuclear magnetic resonance spectroscopy) were evaluated in 15 insulin-resistant and 15 insulin-sensitive lean Asians of Chinese descent with normal glucose tolerance, matched on age, sex, and body mass index. Despite a ~50% lower insulin sensitivity index (Si) in insulin-resistant than in insulin-sensitive subjects, which was accompanied by significantly greater acute insulin response to glucose (AIRg) and fasting insulin concentration but not different fasting glucose concentration, there were no significant differences between groups in the blood lipid profile (p ≥ 0.44) or the lipoprotein subclass concentrations (p ≥ 0.30) and particle sizes (p ≥ 0.43). We conclude that, contrary to observations in subjects with obesity, insulin resistance is not accompanied by unfavorable changes in the plasma lipid profile and lipoprotein particle concentrations and sizes in lean Asians with normal glucose tolerance. Therefore, insulin resistance at the level of glucose metabolism is mechanistically or temporally dissociated from lipid and lipoprotein metabolism. Trial Registration: clinicaltrials.gov, NCT03264001.
AB - Insulin resistance in obesity coincides with abnormalities in lipid profile and lipoprotein subclass distribution and size even before abnormalities in glucose homeostasis manifest. We aimed to assess this relationship in the absence of obesity. Insulin sensitivity (3-h intravenous glucose tolerance test and minimal modeling) and lipoprotein particle concentrations and sizes (proton nuclear magnetic resonance spectroscopy) were evaluated in 15 insulin-resistant and 15 insulin-sensitive lean Asians of Chinese descent with normal glucose tolerance, matched on age, sex, and body mass index. Despite a ~50% lower insulin sensitivity index (Si) in insulin-resistant than in insulin-sensitive subjects, which was accompanied by significantly greater acute insulin response to glucose (AIRg) and fasting insulin concentration but not different fasting glucose concentration, there were no significant differences between groups in the blood lipid profile (p ≥ 0.44) or the lipoprotein subclass concentrations (p ≥ 0.30) and particle sizes (p ≥ 0.43). We conclude that, contrary to observations in subjects with obesity, insulin resistance is not accompanied by unfavorable changes in the plasma lipid profile and lipoprotein particle concentrations and sizes in lean Asians with normal glucose tolerance. Therefore, insulin resistance at the level of glucose metabolism is mechanistically or temporally dissociated from lipid and lipoprotein metabolism. Trial Registration: clinicaltrials.gov, NCT03264001.
KW - Faculty of Science
KW - Insulin resistance
KW - Lipoprotein particle size
KW - Obesity phenotypes
KW - Metabolically-unhealthy lean
KW - Nuclear magnetic resonance
U2 - 10.3389/fnut.2021.651199
DO - 10.3389/fnut.2021.651199
M3 - Journal article
C2 - 33718425
VL - 8
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
SN - 2296-861X
M1 - 651199
ER -
ID: 258659611