Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise
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Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise. / Chooi, Yu Chung; Ding, Cherlyn; Chan, Zhiling; Lo, Jezebel; Choo, John; Ding, Benjamin T K; Leow, Melvin K-S; Magkos, Faidon.
In: Nutrients, Vol. 10, No. 11, 1814, 21.11.2018.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Lipoprotein subclass profile after progressive energy deficits induced by calorie restriction or exercise
AU - Chooi, Yu Chung
AU - Ding, Cherlyn
AU - Chan, Zhiling
AU - Lo, Jezebel
AU - Choo, John
AU - Ding, Benjamin T K
AU - Leow, Melvin K-S
AU - Magkos, Faidon
N1 - CURIS 2018 NEXS 403
PY - 2018/11/21
Y1 - 2018/11/21
N2 - Weight loss, induced by chronic energy deficit, improves the blood lipid profile. However, the effects of an acute negative energy balance and the comparative efficacy of diet and exercise are not well-established. We determined the effects of progressive, acute energy deficits (20% or 40% of daily energy requirements) induced by a single day of calorie restriction (n = 19) or aerobic exercise (n = 13) in healthy subjects (age: 26 ± 9 years; body mass index (BMI): 21.8 ± 2.9 kg/m²). Fasting plasma concentrations of very low-, intermediate-, low-, and high-density lipoprotein (VLDL, LDL, IDL, and HDL, respectively) particles and their subclasses were determined using nuclear magnetic resonance. Total plasma triglyceride and VLDL-triglyceride concentrations decreased after calorie restriction and exercise (all p ≤ 0.025); the pattern of change was linear with an increasing energy deficit (all p < 0.03), with no evidence of plateauing. The number of circulating large and medium VLDL particles decreased after diet and exercise (all p < 0.015), with no change in small VLDL particles. The concentrations of IDL, LDL, and HDL particles, their relative distributions, and the particle sizes were not altered. Our data indicate that an acute negative energy balance induced by calorie restriction and aerobic exercise reduces triglyceride concentrations in a dose-dependent manner, by decreasing circulating large and medium VLDL particles.
AB - Weight loss, induced by chronic energy deficit, improves the blood lipid profile. However, the effects of an acute negative energy balance and the comparative efficacy of diet and exercise are not well-established. We determined the effects of progressive, acute energy deficits (20% or 40% of daily energy requirements) induced by a single day of calorie restriction (n = 19) or aerobic exercise (n = 13) in healthy subjects (age: 26 ± 9 years; body mass index (BMI): 21.8 ± 2.9 kg/m²). Fasting plasma concentrations of very low-, intermediate-, low-, and high-density lipoprotein (VLDL, LDL, IDL, and HDL, respectively) particles and their subclasses were determined using nuclear magnetic resonance. Total plasma triglyceride and VLDL-triglyceride concentrations decreased after calorie restriction and exercise (all p ≤ 0.025); the pattern of change was linear with an increasing energy deficit (all p < 0.03), with no evidence of plateauing. The number of circulating large and medium VLDL particles decreased after diet and exercise (all p < 0.015), with no change in small VLDL particles. The concentrations of IDL, LDL, and HDL particles, their relative distributions, and the particle sizes were not altered. Our data indicate that an acute negative energy balance induced by calorie restriction and aerobic exercise reduces triglyceride concentrations in a dose-dependent manner, by decreasing circulating large and medium VLDL particles.
KW - Faculty of Science
KW - Lipoproteins
KW - Triglyceride
KW - Cholesterol
KW - Negative energy balance
U2 - 10.3390/nu10111814
DO - 10.3390/nu10111814
M3 - Journal article
C2 - 30469333
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 11
M1 - 1814
ER -
ID: 209258572