Nanocarriers of antigen proteins for vaccine delivery

Research output: Contribution to journalReviewResearchpeer-review

  • Luíse Lopes Chaves
  • Douglas Dourado
  • Ioana-Bianca Prunache
  • Paloma Manuelle Marques da Silva
  • Gislayne Tacyana Dos Santos Lucena
  • Zilyane Cardoso de Souza
  • Patrícia Muniz Mendes Freire de Moura
  • Nunes Bordallo, Heloisa
  • Fabio Rocha Formiga
  • Juliana de Souza Rebouças

Nanoformulations in vaccinology provide antigen stability and enhanced immunogenicity, in addition to providing targeted delivery and controlled release. In the last years, much research has been focused on vaccine development using virus-like particles, liposomes, emulsions, polymeric, lipid, and inorganic nanoparticles. Importantly, nanoparticle interactions with innate and adaptive immune systems must be clearly understood to guide the rational development of nanovaccines. This review provides a recap and updates on different aspects advocating nanoparticles as promising antigen carriers and immune cell activators for vaccination. Moreover, it offers a discussion of how the physicochemical properties of nanoparticles are modified to target specific cells and improve vaccine efficacy.

Original languageEnglish
Article number124162
JournalInternational Journal of Pharmaceutics
Volume659
Number of pages11
ISSN0378-5173
DOIs
Publication statusPublished - 25 Jun 2024

Bibliographical note

Copyright © 2024. Published by Elsevier B.V.

    Research areas

  • Humans, Vaccines/administration & dosage, Animals, Nanoparticles, Antigens/administration & dosage, Drug Carriers/chemistry, Drug Delivery Systems/methods, Nanoparticle Drug Delivery System/chemistry

ID: 397936116