The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme: A PREVIEW sub-study
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The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme: A PREVIEW sub-study. / Møller, Grith; Andersen, Jens Rikardt; Jalo, Elli; Ritz, Christian; Brand-Miller, J; Larsen, Thomas Meinert; Silvestre, Marta P; Fogelholm, M; Poppitt, Sally D; Raben, Anne; Dragsted, Lars Ove.
In: European Journal of Nutrition, Vol. 59, No. 4, 2020, p. 1517-1527.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The association of dietary animal and plant protein with putative risk markers of colorectal cancer in overweight pre-diabetic individuals during a weight-reducing programme: A PREVIEW sub-study
AU - Møller, Grith
AU - Andersen, Jens Rikardt
AU - Jalo, Elli
AU - Ritz, Christian
AU - Brand-Miller, J
AU - Larsen, Thomas Meinert
AU - Silvestre, Marta P
AU - Fogelholm, M
AU - Poppitt, Sally D
AU - Raben, Anne
AU - Dragsted, Lars Ove
N1 - CURIS 2020 NEXS 152
PY - 2020
Y1 - 2020
N2 - Purpose: Diets with increased protein content are popular strategies for body weight regulation, but the effect of such diets for the colonic luminal environment is unclear. We aimed to investigate the associations between putative colorectal cancerrelated markers and total protein intake, plant and animal proteins, and protein from red and processed meat in pre-diabeticadults (> 25 years).Methods: Analyses were based on clinical and dietary assessments at baseline and after 1 year of intervention. Protein intake was assessed from 4-day dietary records. Putative colorectal cancer-related markers identified from 24-h faecal samples collected over three consecutive days were: concentration of short-chain fatty acids, phenols, ammonia, and pH.Results: In total, 79 participants were included in the analyses. We found a positive association between change in total protein intake (slope: 74.72 ± 28.84 μmol per g faeces/E%, p = 0.01), including animal protein intake (slope: 87.63 ± 32.04 μmol per g faeces/E%, p = 0.009), and change in faecal ammonia concentration. For change in ammonia, there was a dose–response trend from the most negative (lowest tertile) to the most positive (highest tertile) association (p = 0.01): in the high tertile, a change in intake of red meat was positively associated with an increase in ammonia excretion (slope: 2.0 ± 0.5 μmol per gfaeces/g/day, p < 0.001), whereas no such association was found in the low and medium tertile groups.Conclusion: Increases in total and animal protein intakes were associated with higher excretion of ammonia in faeces after 1 year in overweight pre-diabetic adults undertaking a weight-loss intervention. An increase in total or relative protein intake, or in the ratio of animal to plant protein, was not associated with an increase in faeces of any of the other putative colorectal cancer risk markers.Trial registration: ClinicalTrials.gov Identifier: NCT01777893.
AB - Purpose: Diets with increased protein content are popular strategies for body weight regulation, but the effect of such diets for the colonic luminal environment is unclear. We aimed to investigate the associations between putative colorectal cancerrelated markers and total protein intake, plant and animal proteins, and protein from red and processed meat in pre-diabeticadults (> 25 years).Methods: Analyses were based on clinical and dietary assessments at baseline and after 1 year of intervention. Protein intake was assessed from 4-day dietary records. Putative colorectal cancer-related markers identified from 24-h faecal samples collected over three consecutive days were: concentration of short-chain fatty acids, phenols, ammonia, and pH.Results: In total, 79 participants were included in the analyses. We found a positive association between change in total protein intake (slope: 74.72 ± 28.84 μmol per g faeces/E%, p = 0.01), including animal protein intake (slope: 87.63 ± 32.04 μmol per g faeces/E%, p = 0.009), and change in faecal ammonia concentration. For change in ammonia, there was a dose–response trend from the most negative (lowest tertile) to the most positive (highest tertile) association (p = 0.01): in the high tertile, a change in intake of red meat was positively associated with an increase in ammonia excretion (slope: 2.0 ± 0.5 μmol per gfaeces/g/day, p < 0.001), whereas no such association was found in the low and medium tertile groups.Conclusion: Increases in total and animal protein intakes were associated with higher excretion of ammonia in faeces after 1 year in overweight pre-diabetic adults undertaking a weight-loss intervention. An increase in total or relative protein intake, or in the ratio of animal to plant protein, was not associated with an increase in faeces of any of the other putative colorectal cancer risk markers.Trial registration: ClinicalTrials.gov Identifier: NCT01777893.
KW - Faculty of Science
KW - Dietary protein
KW - Faecal
KW - SCFA
KW - pH
KW - Ammonia
KW - Phenols
U2 - 10.1007/s00394-019-02008-2
DO - 10.1007/s00394-019-02008-2
M3 - Journal article
C2 - 31139889
VL - 59
SP - 1517
EP - 1527
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
IS - 4
ER -
ID: 218709305