Translation attenuation mechanism in unfolded protein response
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.
Original language | English |
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Title of host publication | Evolution from Cellular to Social Scales |
Editors | Arne Skjeltorp, Arne Skjeltorp, Alexander Belushkin |
Number of pages | 8 |
Publication date | 1 Dec 2008 |
Pages | 83-90 |
ISBN (Print) | 9781402087608 |
DOIs | |
Publication status | Published - 1 Dec 2008 |
Series | NATO Science for Peace and Security Series B: Physics and Biophysics |
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ISSN | 1874-6500 |
- Stress response, Translational attenuation, Unfolded protein response, UPR
Research areas
ID: 229440002