Why do phage play dice?

Research output: Contribution to journal › Journal article › Research › peer-review

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Why do phage play dice? / Avlund, Mikkel; Dodd, Ian B; Semsey, Szabolcs; Sneppen, Kim; Krishna, Sandeep.

In: Journal of Virology, Vol. 83, No. 22, 11.2009, p. 11416-20.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Avlund, M, Dodd, IB, Semsey, S, Sneppen, K & Krishna, S 2009, 'Why do phage play dice?', Journal of Virology, vol. 83, no. 22, pp. 11416-20. https://doi.org/10.1128/JVI.01057-09

APA

Avlund, M., Dodd, I. B., Semsey, S., Sneppen, K., & Krishna, S. (2009). Why do phage play dice? Journal of Virology, 83(22), 11416-20. https://doi.org/10.1128/JVI.01057-09

Vancouver

Avlund M, Dodd IB, Semsey S, Sneppen K, Krishna S. Why do phage play dice? Journal of Virology. 2009 Nov;83(22):11416-20. https://doi.org/10.1128/JVI.01057-09

Author

Avlund, Mikkel ; Dodd, Ian B ; Semsey, Szabolcs ; Sneppen, Kim ; Krishna, Sandeep. / Why do phage play dice?. In: Journal of Virology. 2009 ; Vol. 83, No. 22. pp. 11416-20.

Bibtex

@article{c1b8aea32e3b4f659661b5c876a7c149,
title = "Why do phage play dice?",
abstract = "Phage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a {"}game{"} of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage.",
keywords = "Bacteriophage lambda, Game Theory, Lysogeny, Probability, Stochastic Processes, Virus Activation, Journal Article, Research Support, Non-U.S. Gov't",
author = "Mikkel Avlund and Dodd, {Ian B} and Szabolcs Semsey and Kim Sneppen and Sandeep Krishna",
year = "2009",
month = nov,
doi = "10.1128/JVI.01057-09",
language = "English",
volume = "83",
pages = "11416--20",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "22",

}

RIS

TY - JOUR

T1 - Why do phage play dice?

AU - Avlund, Mikkel

AU - Dodd, Ian B

AU - Semsey, Szabolcs

AU - Sneppen, Kim

AU - Krishna, Sandeep

PY - 2009/11

Y1 - 2009/11

N2 - Phage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a "game" of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage.

AB - Phage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a "game" of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage.

KW - Bacteriophage lambda

KW - Game Theory

KW - Lysogeny

KW - Probability

KW - Stochastic Processes

KW - Virus Activation

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1128/JVI.01057-09

DO - 10.1128/JVI.01057-09

M3 - Journal article

C2 - 19740995

VL - 83

SP - 11416

EP - 11420

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 22

ER -

ID: 163917171