4.5S RNA: does form predict function?
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4.5S RNA: does form predict function? / Brown, S.
I: The New Biologist, Bind 3, Nr. 5, 1991, s. 430-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - 4.5S RNA: does form predict function?
AU - Brown, S
N1 - Keywords: Base Sequence; Escherichia coli; Humans; Molecular Sequence Data; Protein Biosynthesis; RNA; RNA, Bacterial; RNA, Small Nuclear; Ribosomes; Sequence Homology, Nucleic Acid; Structure-Activity Relationship
PY - 1991
Y1 - 1991
N2 - 4.5S RNA is a stable RNA of Escherichia coli, and functional homologs of the molecule apparently exist in all prokaryotes: eubacteria, archebacteria, and mycoplasma. Genetic and physiological measurements of the function of 4.5S RNA in E. coli indicate a role for this RNA in protein synthesis. A conserved domain of 4.5S RNA displays structural similarity with the eukaryotic 7S RNA that functions in protein secretion. Although complementation by eukaryotic 7S RNAs remains to be demonstrated, a number of archaebacterial 7S RNAs are able to replace 4.5S RNA for growth of E. coli, and 4.5S RNA is able to mediate a number of 7S RNA functions in vitro. Surprisingly, no effects on protein secretion in E. coli have been directly attributed to 4.5S RNA. These observations raise the question of whether molecules of similar structure necessarily perform the same function.
AB - 4.5S RNA is a stable RNA of Escherichia coli, and functional homologs of the molecule apparently exist in all prokaryotes: eubacteria, archebacteria, and mycoplasma. Genetic and physiological measurements of the function of 4.5S RNA in E. coli indicate a role for this RNA in protein synthesis. A conserved domain of 4.5S RNA displays structural similarity with the eukaryotic 7S RNA that functions in protein secretion. Although complementation by eukaryotic 7S RNAs remains to be demonstrated, a number of archaebacterial 7S RNAs are able to replace 4.5S RNA for growth of E. coli, and 4.5S RNA is able to mediate a number of 7S RNA functions in vitro. Surprisingly, no effects on protein secretion in E. coli have been directly attributed to 4.5S RNA. These observations raise the question of whether molecules of similar structure necessarily perform the same function.
M3 - Journal article
C2 - 1715753
VL - 3
SP - 430
EP - 438
JO - The New Biologist
JF - The New Biologist
SN - 1043-4674
IS - 5
ER -
ID: 9298303