Autotoxin-mediated latecomer killing in yeast communities
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Autotoxin-mediated latecomer killing in yeast communities. / Oda, Arisa H.; Tamura, Miki; Kaneko, Kunihiko; Ohta, Kunihiro; Hatakeyama, Tetsuhiro S.
I: PLOS Biology, Bind 20, Nr. 11, 3001844, 07.11.2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Autotoxin-mediated latecomer killing in yeast communities
AU - Oda, Arisa H.
AU - Tamura, Miki
AU - Kaneko, Kunihiko
AU - Ohta, Kunihiro
AU - Hatakeyama, Tetsuhiro S.
PY - 2022/11/7
Y1 - 2022/11/7
N2 - Cellular adaptation to stressful environments such as starvation is essential to the survival of microbial communities, but the uniform response of the cell community may lead to entire cell death or severe damage to their fitness. Here, we demonstrate an elaborate response of the yeast community against glucose depletion, in which the first adapted cells kill the latecomer cells. During glucose depletion, yeast cells release autotoxins, such as leucic acid and L-2keto-3methylvalerate, which can even kill the clonal cells of the ones producing them. Although these autotoxins were likely to induce mass suicide, some cells differentiated to adapt to the autotoxins without genetic changes. If nondifferentiated latecomers tried to invade the habitat, autotoxins damaged or killed the latecomers, but the differentiated cells could selectively survive. Phylogenetically distant fission and budding yeast shared this behavior using the same autotoxins, suggesting that latecomer killing may be the universal system of intercellular communication, which may be relevant to the evolutional transition from unicellular to multicellular organisms.
AB - Cellular adaptation to stressful environments such as starvation is essential to the survival of microbial communities, but the uniform response of the cell community may lead to entire cell death or severe damage to their fitness. Here, we demonstrate an elaborate response of the yeast community against glucose depletion, in which the first adapted cells kill the latecomer cells. During glucose depletion, yeast cells release autotoxins, such as leucic acid and L-2keto-3methylvalerate, which can even kill the clonal cells of the ones producing them. Although these autotoxins were likely to induce mass suicide, some cells differentiated to adapt to the autotoxins without genetic changes. If nondifferentiated latecomers tried to invade the habitat, autotoxins damaged or killed the latecomers, but the differentiated cells could selectively survive. Phylogenetically distant fission and budding yeast shared this behavior using the same autotoxins, suggesting that latecomer killing may be the universal system of intercellular communication, which may be relevant to the evolutional transition from unicellular to multicellular organisms.
KW - SCHIZOSACCHAROMYCES-POMBE
KW - CELL-DEATH
KW - EVOLUTION
KW - APOPTOSIS
KW - MUTANTS
KW - GENE
KW - IDENTIFICATION
KW - ANTAGONISM
KW - AUTOPHAGY
KW - BIOFILMS
U2 - 10.1371/journal.pbio.3001844
DO - 10.1371/journal.pbio.3001844
M3 - Journal article
C2 - 36342925
VL - 20
JO - PLoS Biology
JF - PLoS Biology
SN - 1544-9173
IS - 11
M1 - 3001844
ER -
ID: 337351549