Bifractal nature of chromosome contact maps
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Bifractal nature of chromosome contact maps. / Pigolotti, Simone; Jensen, Mogens H.; Zhan, Yinxiu; Tiana, Guido.
I: Physical Review Research, Bind 2, Nr. 4, 043078, 15.10.2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Bifractal nature of chromosome contact maps
AU - Pigolotti, Simone
AU - Jensen, Mogens H.
AU - Zhan, Yinxiu
AU - Tiana, Guido
PY - 2020/10/15
Y1 - 2020/10/15
N2 - Modern biological techniques such as Hi-C permit one to measure probabilities that different chromosomal regions are close in space. These probabilities can be visualized as matrices called contact maps. In this paper, we introduce a multifractal analysis of chromosomal contact maps. Our analysis reveals that Hi-C maps are bifractal, i.e., complex geometrical objects characterized by two distinct fractal dimensions. To rationalize this observation, we introduce a model that describes chromosomes as a hierarchical set of nested domains and we solve it exactly. The predicted multifractal spectrum is in excellent quantitative agreement with experimental data. Moreover, we show that our theory yields a more robust estimation of the scaling exponent of the contact probability than existing methods. By applying this method to experimental data, we detect subtle conformational changes among chromosomes during differentiation of human stem cells.
AB - Modern biological techniques such as Hi-C permit one to measure probabilities that different chromosomal regions are close in space. These probabilities can be visualized as matrices called contact maps. In this paper, we introduce a multifractal analysis of chromosomal contact maps. Our analysis reveals that Hi-C maps are bifractal, i.e., complex geometrical objects characterized by two distinct fractal dimensions. To rationalize this observation, we introduce a model that describes chromosomes as a hierarchical set of nested domains and we solve it exactly. The predicted multifractal spectrum is in excellent quantitative agreement with experimental data. Moreover, we show that our theory yields a more robust estimation of the scaling exponent of the contact probability than existing methods. By applying this method to experimental data, we detect subtle conformational changes among chromosomes during differentiation of human stem cells.
KW - 3D GENOME
KW - DOMAINS
KW - ORGANIZATION
KW - PRINCIPLES
KW - FLUCTUATIONS
KW - CONFORMATION
KW - ACTIVATION
KW - INSULATION
KW - SCALE
U2 - 10.1103/PhysRevResearch.2.043078
DO - 10.1103/PhysRevResearch.2.043078
M3 - Journal article
VL - 2
JO - Physical Review Research
JF - Physical Review Research
SN - 2643-1564
IS - 4
M1 - 043078
ER -
ID: 255734693