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Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites. / Sabbatini, Paola; Wellendorph, Petrine; Høg, Signe; Pedersen, Martin Holst Friborg; Bräuner-Osborne, Hans; Martiny, Lars; Frølund, Bente Flensborg; Clausen, Rasmus Prætorius.
I:
Journal of Medicinal Chemistry, Bind 53, Nr. 17, 2010, s. 6506-6510.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Sabbatini, P
, Wellendorph, P, Høg, S, Pedersen, MHF
, Bräuner-Osborne, H, Martiny, L
, Frølund, BF & Clausen, RP 2010, '
Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites',
Journal of Medicinal Chemistry, bind 53, nr. 17, s. 6506-6510.
https://doi.org/10.1021/jm1006325
APA
Sabbatini, P.
, Wellendorph, P., Høg, S., Pedersen, M. H. F.
, Bräuner-Osborne, H., Martiny, L.
, Frølund, B. F., & Clausen, R. P. (2010).
Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites.
Journal of Medicinal Chemistry,
53(17), 6506-6510.
https://doi.org/10.1021/jm1006325
Vancouver
Sabbatini P
, Wellendorph P, Høg S, Pedersen MHF
, Bräuner-Osborne H, Martiny L o.a.
Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites.
Journal of Medicinal Chemistry. 2010;53(17):6506-6510.
https://doi.org/10.1021/jm1006325
Author
Sabbatini, Paola ; Wellendorph, Petrine ; Høg, Signe ; Pedersen, Martin Holst Friborg ; Bräuner-Osborne, Hans ; Martiny, Lars ; Frølund, Bente Flensborg ; Clausen, Rasmus Prætorius. / Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites. I: Journal of Medicinal Chemistry. 2010 ; Bind 53, Nr. 17. s. 6506-6510.
Bibtex
@article{66fd0990b75011df825b000ea68e967b,
title = "Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites",
abstract = "gamma-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first (125)I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Paola Sabbatini and Petrine Wellendorph and Signe H{\o}g and Pedersen, {Martin Holst Friborg} and Hans Br{\"a}uner-Osborne and Lars Martiny and Fr{\o}lund, {Bente Flensborg} and Clausen, {Rasmus Pr{\ae}torius}",
year = "2010",
doi = "10.1021/jm1006325",
language = "English",
volume = "53",
pages = "6506--6510",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "17",
}
RIS
TY - JOUR
T1 - Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites
AU - Sabbatini, Paola
AU - Wellendorph, Petrine
AU - Høg, Signe
AU - Pedersen, Martin Holst Friborg
AU - Bräuner-Osborne, Hans
AU - Martiny, Lars
AU - Frølund, Bente Flensborg
AU - Clausen, Rasmus Prætorius
PY - 2010
Y1 - 2010
N2 - gamma-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first (125)I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.
AB - gamma-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first (125)I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1021/jm1006325
DO - 10.1021/jm1006325
M3 - Journal article
C2 - 20715819
VL - 53
SP - 6506
EP - 6510
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 17
ER -