Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
gamma-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first (125)I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Medicinal Chemistry |
Vol/bind | 53 |
Udgave nummer | 17 |
Sider (fra-til) | 6506-6510 |
ISSN | 0022-2623 |
DOI | |
Status | Udgivet - 2010 |
- Det tidligere Farmaceutiske Fakultet
Forskningsområder
ID: 21772547