How Membrane Geometry Regulates Protein Sorting Independently of Mean Curvature
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Biological membranes have distinct geometries that confer specific functions. However, the molecular mechanisms underlying the phenomenological geometry/function correlations remain elusive. We studied the effect of membrane geometry on the localization of membrane-bound proteins. Quantitative comparative experiments between the two most abundant cellular membrane geometries, spherical and cylindrical, revealed that geometry regulates the spatial segregation of proteins. The measured geometry-driven segregation reached 50-fold for membranes of the same mean curvature, demonstrating a crucial and hitherto unaccounted contribution by Gaussian curvature. Molecular-field theory calculations elucidated the underlying physical and molecular mechanisms. Our results reveal that distinct membrane geometries have specific physicochemical properties and thus establish a ubiquitous mechanistic foundation for unravelling the conserved correlations between biological function and membrane polymorphism.
Originalsprog | Engelsk |
---|---|
Tidsskrift | ACS Central Science |
Vol/bind | 6 |
Udgave nummer | 7 |
Sider (fra-til) | 1159-1168 |
Antal sider | 10 |
ISSN | 2374-7943 |
DOI | |
Status | Udgivet - 2020 |
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379390/pdf/oc0c00419.pdf
Forlagets udgivne version
ID: 247155911