Bone mass development is sensitive to insulin resistance in adolescent boys
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Bone mass development is sensitive to insulin resistance in adolescent boys. / Rønne, Maria Sode; Heidemann, Malene; Lylloff, Louise; Schou, Anders J; Tarp, Jakob; Bugge, Anna; Laursen, Jens Ole; Jørgensen, Niklas Rye; Husby, Steffen; Wedderkopp, Niels; Mølgaard, Christian.
In: Bone, Vol. 122, 2019, p. 1-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Bone mass development is sensitive to insulin resistance in adolescent boys
AU - Rønne, Maria Sode
AU - Heidemann, Malene
AU - Lylloff, Louise
AU - Schou, Anders J
AU - Tarp, Jakob
AU - Bugge, Anna
AU - Laursen, Jens Ole
AU - Jørgensen, Niklas Rye
AU - Husby, Steffen
AU - Wedderkopp, Niels
AU - Mølgaard, Christian
N1 - CURIS 2019 NEXS 058
PY - 2019
Y1 - 2019
N2 - Purpose: Insulin resistance may exert a negative influence on bone mass in childhood and adolescence. The objective was to assess the association between insulin resistance and total body less head (TBLH) bone mineral content (BMC) and to investigate whether body composition, physical activity or osteocalcin levels may influence this association.Methods: A longitudinal study with follow-up over >6 years was performed and included 562 apparently healthy participants with a mean age of 9.6 years at baseline. Participants underwent DXA scanning at baseline. At the two follow-ups, participants had performed another DXA scanning, had blood samples taken for fasting insulin, glucose and osteocalcin and had physical activity measured with an accelerometer. HOMA-IR was calculated as an index of insulin resistance.Results: HOMA-IR was negatively associated with TBLH BMC in boys at follow-ups (β = -31.4, p < 0.001) after adjustment for maturity, height, bone area, and baseline level of TBLH BMC. The negative association remained almost unchanged after further adjustments for body composition and physical activity. No association between HOMA-IR and TBLH BMC was found in girls.Conclusion: Insulin resistance may be detrimental for bone development through puberty in boys independent of body composition and the level of physical activity.
AB - Purpose: Insulin resistance may exert a negative influence on bone mass in childhood and adolescence. The objective was to assess the association between insulin resistance and total body less head (TBLH) bone mineral content (BMC) and to investigate whether body composition, physical activity or osteocalcin levels may influence this association.Methods: A longitudinal study with follow-up over >6 years was performed and included 562 apparently healthy participants with a mean age of 9.6 years at baseline. Participants underwent DXA scanning at baseline. At the two follow-ups, participants had performed another DXA scanning, had blood samples taken for fasting insulin, glucose and osteocalcin and had physical activity measured with an accelerometer. HOMA-IR was calculated as an index of insulin resistance.Results: HOMA-IR was negatively associated with TBLH BMC in boys at follow-ups (β = -31.4, p < 0.001) after adjustment for maturity, height, bone area, and baseline level of TBLH BMC. The negative association remained almost unchanged after further adjustments for body composition and physical activity. No association between HOMA-IR and TBLH BMC was found in girls.Conclusion: Insulin resistance may be detrimental for bone development through puberty in boys independent of body composition and the level of physical activity.
KW - Faculty of Science
KW - Bone mass
KW - Puberty
KW - HOMA-IR
KW - Physical activity
KW - Dual energy X-ray absorptiometry
U2 - 10.1016/j.bone.2019.02.005
DO - 10.1016/j.bone.2019.02.005
M3 - Journal article
C2 - 30738213
VL - 122
SP - 1
EP - 7
JO - Bone
JF - Bone
SN - 8756-3282
ER -
ID: 213152626