The role of gluten in multiple sclerosis: A systematic review
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The role of gluten in multiple sclerosis : A systematic review. / Thomsen, Henriette Lynge; Jessen, Elise Barsøe; Passali, Moschoula; Frederiksen, Jette Lautrup.
In: Multiple Sclerosis and Related Disorders, Vol. 27, 2019, p. 156-163.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The role of gluten in multiple sclerosis
T2 - A systematic review
AU - Thomsen, Henriette Lynge
AU - Jessen, Elise Barsøe
AU - Passali, Moschoula
AU - Frederiksen, Jette Lautrup
N1 - CURIS 2019 NEXS 026
PY - 2019
Y1 - 2019
N2 - Background: There is an increasing interest in diet as a modifying factor in multiple sclerosis (MS), and gluten has been suggested to affect MS.Objective: The aim of this systematic review is to qualitatively evaluate the evidence on the role of gluten in MS.Methods: A review protocol was submitted to PROSPERO. A systematic literature search was conducted in PubMed, Web of Science, Scopus, Embase, Cab Abstracts, and Google Scholar. Studies on patients with MS, clinically isolated syndrome, or celiac disease presenting with MS-related markers were included, if they investigated effects of diets containing specified amounts of gluten or associations between gluten sensitivities and MS.Results: Forty-nine publications presenting 50 studies/cases met the inclusion criteria. Study designs, methods, and outcomes varied broadly across studies. Two intervention studies found a positive effect of a gluten-free diet on disease-related markers in patients with MS. One prospective cohort study also found a positive effect of a gluten-free diet, while a survey found intake of cereal/bread to be protective against MS. Four observational studies did not find increased comorbidity of MS and celiac disease. Seventeen studies investigated the level of different gluten-sensitivity markers in patients with MS with inconsistent results. Finally, 12 cases and 13 posters/abstracts/master's theses contributed to shed light on the topic.Conclusions: There is still not sufficient evidence to state whether gluten plays a role in MS, but limitations of current evidence have been identified and directions of future research have been suggested.
AB - Background: There is an increasing interest in diet as a modifying factor in multiple sclerosis (MS), and gluten has been suggested to affect MS.Objective: The aim of this systematic review is to qualitatively evaluate the evidence on the role of gluten in MS.Methods: A review protocol was submitted to PROSPERO. A systematic literature search was conducted in PubMed, Web of Science, Scopus, Embase, Cab Abstracts, and Google Scholar. Studies on patients with MS, clinically isolated syndrome, or celiac disease presenting with MS-related markers were included, if they investigated effects of diets containing specified amounts of gluten or associations between gluten sensitivities and MS.Results: Forty-nine publications presenting 50 studies/cases met the inclusion criteria. Study designs, methods, and outcomes varied broadly across studies. Two intervention studies found a positive effect of a gluten-free diet on disease-related markers in patients with MS. One prospective cohort study also found a positive effect of a gluten-free diet, while a survey found intake of cereal/bread to be protective against MS. Four observational studies did not find increased comorbidity of MS and celiac disease. Seventeen studies investigated the level of different gluten-sensitivity markers in patients with MS with inconsistent results. Finally, 12 cases and 13 posters/abstracts/master's theses contributed to shed light on the topic.Conclusions: There is still not sufficient evidence to state whether gluten plays a role in MS, but limitations of current evidence have been identified and directions of future research have been suggested.
KW - Faculty of Science
KW - Clinically isolated syndrome
KW - Diet
KW - Gliadin
KW - Gluten
KW - Multiple sclerosis
U2 - 10.1016/j.msard.2018.10.019
DO - 10.1016/j.msard.2018.10.019
M3 - Review
C2 - 30384202
VL - 27
SP - 156
EP - 163
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
SN - 2211-0348
ER -
ID: 211988693