A Wnt oscillator model for somitogenesis

Niels Bohr Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A Wnt oscillator model for somitogenesis. / Jensen, Peter B; Pedersen, Lykke; Krishna, Sandeep; Jensen, Mogens H.

In: Biophysical Journal, Vol. 98, No. 6, 17.03.2010, p. 943-950.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jensen, PB, Pedersen, L, Krishna, S & Jensen, MH 2010, 'A Wnt oscillator model for somitogenesis', Biophysical Journal, vol. 98, no. 6, pp. 943-950. https://doi.org/10.1016/j.bpj.2009.11.039

APA

Jensen, P. B., Pedersen, L., Krishna, S., & Jensen, M. H. (2010). A Wnt oscillator model for somitogenesis. Biophysical Journal, 98(6), 943-950. https://doi.org/10.1016/j.bpj.2009.11.039

Vancouver

Jensen PB, Pedersen L, Krishna S, Jensen MH. A Wnt oscillator model for somitogenesis. Biophysical Journal. 2010 Mar 17;98(6):943-950. https://doi.org/10.1016/j.bpj.2009.11.039

Author

Jensen, Peter B ; Pedersen, Lykke ; Krishna, Sandeep ; Jensen, Mogens H. / A Wnt oscillator model for somitogenesis. In: Biophysical Journal. 2010 ; Vol. 98, No. 6. pp. 943-950.

Bibtex

@article{0af626c0fc2e4ff8b75b5cab57a79599,

title = "A Wnt oscillator model for somitogenesis",

abstract = "We propose a model for the segmentation clock in vertebrate somitogenesis, based on the Wnt signaling pathway. The core of the model is a negative feedback loop centered around the Axin2 protein. Axin2 is activated by beta-catenin, which in turn is degraded by a complex of GSK3beta and Axin2. The model produces oscillatory states of the involved constituents with typical time periods of a few hours (ultradian oscillations). The oscillations are robust to changes in parameter values and are often spiky, where low concentration values of beta-catenin are interrupted by sharp peaks. Necessary for the oscillations is the saturated degradation of Axin2. Somite formation in chick and mouse embryos is controlled by a spatial Wnt gradient which we introduce in the model through a time-dependent decrease in Wnt3a ligand level. We find that the oscillations disappear as the ligand concentration decreases, in agreement with observations on embryos.",

keywords = "Animals, Biological Clocks, Computer Simulation, Embryonic Development, Humans, Models, Biological, Somites, Wnt Proteins",

author = "Jensen, {Peter B} and Lykke Pedersen and Sandeep Krishna and Jensen, {Mogens H}",

year = "2010",

month = mar,

day = "17",

doi = "10.1016/j.bpj.2009.11.039",

language = "English",

volume = "98",

pages = "943--950",

journal = "Biophysical Journal",

issn = "0006-3495",

publisher = "Cell Press",

number = "6",

}

RIS

TY - JOUR

T1 - A Wnt oscillator model for somitogenesis

AU - Jensen, Peter B

AU - Pedersen, Lykke

AU - Krishna, Sandeep

AU - Jensen, Mogens H

PY - 2010/3/17

Y1 - 2010/3/17

N2 - We propose a model for the segmentation clock in vertebrate somitogenesis, based on the Wnt signaling pathway. The core of the model is a negative feedback loop centered around the Axin2 protein. Axin2 is activated by beta-catenin, which in turn is degraded by a complex of GSK3beta and Axin2. The model produces oscillatory states of the involved constituents with typical time periods of a few hours (ultradian oscillations). The oscillations are robust to changes in parameter values and are often spiky, where low concentration values of beta-catenin are interrupted by sharp peaks. Necessary for the oscillations is the saturated degradation of Axin2. Somite formation in chick and mouse embryos is controlled by a spatial Wnt gradient which we introduce in the model through a time-dependent decrease in Wnt3a ligand level. We find that the oscillations disappear as the ligand concentration decreases, in agreement with observations on embryos.

AB - We propose a model for the segmentation clock in vertebrate somitogenesis, based on the Wnt signaling pathway. The core of the model is a negative feedback loop centered around the Axin2 protein. Axin2 is activated by beta-catenin, which in turn is degraded by a complex of GSK3beta and Axin2. The model produces oscillatory states of the involved constituents with typical time periods of a few hours (ultradian oscillations). The oscillations are robust to changes in parameter values and are often spiky, where low concentration values of beta-catenin are interrupted by sharp peaks. Necessary for the oscillations is the saturated degradation of Axin2. Somite formation in chick and mouse embryos is controlled by a spatial Wnt gradient which we introduce in the model through a time-dependent decrease in Wnt3a ligand level. We find that the oscillations disappear as the ligand concentration decreases, in agreement with observations on embryos.

KW - Animals

KW - Biological Clocks

KW - Computer Simulation

KW - Embryonic Development

KW - Humans

KW - Models, Biological

KW - Somites

KW - Wnt Proteins

U2 - 10.1016/j.bpj.2009.11.039

DO - 10.1016/j.bpj.2009.11.039

M3 - Journal article

C2 - 20303851

VL - 98

SP - 943

EP - 950

JO - Biophysical Journal

JF - Biophysical Journal

SN - 0006-3495

IS - 6

ER -

ID: 32671790