Coupled oscillator cooperativity as a control mechanism in chronobiology

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Coupled oscillator cooperativity as a control mechanism in chronobiology. / Heltberg, Mathias S.; Jiang, Yuanxu; Fan, Yingying; Zhang, Zhibo; Nordentoft, Malthe S.; Lin, Wei; Qian, Long; Ouyang, Qi; Jensen, Mogens H.; Wei, Ping.

In: Cell Systems, Vol. 14, No. 5, 17.05.2023, p. 382-391.e5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Heltberg, MS, Jiang, Y, Fan, Y, Zhang, Z, Nordentoft, MS, Lin, W, Qian, L, Ouyang, Q, Jensen, MH & Wei, P 2023, 'Coupled oscillator cooperativity as a control mechanism in chronobiology', Cell Systems, vol. 14, no. 5, pp. 382-391.e5. https://doi.org/10.1016/j.cels.2023.04.001

APA

Heltberg, M. S., Jiang, Y., Fan, Y., Zhang, Z., Nordentoft, M. S., Lin, W., Qian, L., Ouyang, Q., Jensen, M. H., & Wei, P. (2023). Coupled oscillator cooperativity as a control mechanism in chronobiology. Cell Systems, 14(5), 382-391.e5. https://doi.org/10.1016/j.cels.2023.04.001

Vancouver

Heltberg MS, Jiang Y, Fan Y, Zhang Z, Nordentoft MS, Lin W et al. Coupled oscillator cooperativity as a control mechanism in chronobiology. Cell Systems. 2023 May 17;14(5):382-391.e5. https://doi.org/10.1016/j.cels.2023.04.001

Author

Heltberg, Mathias S. ; Jiang, Yuanxu ; Fan, Yingying ; Zhang, Zhibo ; Nordentoft, Malthe S. ; Lin, Wei ; Qian, Long ; Ouyang, Qi ; Jensen, Mogens H. ; Wei, Ping. / Coupled oscillator cooperativity as a control mechanism in chronobiology. In: Cell Systems. 2023 ; Vol. 14, No. 5. pp. 382-391.e5.

Bibtex

@article{74b304110cf744159521010f25036342,

title = "Coupled oscillator cooperativity as a control mechanism in chronobiology",

abstract = "Control of dynamical processes is vital for maintaining correct cell regulation and cell-fate decisions. Numerous regulatory networks show oscillatory behavior; however, our knowledge of how one oscillator behaves when stimulated by two or more external oscillatory signals is still missing. We explore this problem by constructing a synthetic oscillatory system in yeast and stimulate it with two external oscillatory signals. Letting model verification and prediction operate in a tight interplay with experimental observations, we find that stimulation with two external signals expands the plateau of entrainment and reduces the fluctuations of oscillations. Furthermore, by adjusting the phase differences of external signals, one can control the amplitude of oscillations, which is understood through the signal delay of the unperturbed oscillatory network. With this we reveal a direct amplitude dependency of downstream gene transcription. Taken together, these results suggest a new path to control oscillatory systems by coupled oscillator cooperativity.",

keywords = "coupled oscillators, entrainment, phase modulation, biological oscillation, synthetic biology, Arnold tongues, chronobiology, NF-κB, signaling dynamics",

author = "Heltberg, {Mathias S.} and Yuanxu Jiang and Yingying Fan and Zhibo Zhang and Nordentoft, {Malthe S.} and Wei Lin and Long Qian and Qi Ouyang and Jensen, {Mogens H.} and Ping Wei",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = may,

day = "17",

doi = "10.1016/j.cels.2023.04.001",

language = "English",

volume = "14",

pages = "382--391.e5",

journal = "Cell Systems",

issn = "2405-4712",

publisher = "Cell Press",

number = "5",

}

RIS

TY - JOUR

T1 - Coupled oscillator cooperativity as a control mechanism in chronobiology

AU - Heltberg, Mathias S.

AU - Jiang, Yuanxu

AU - Fan, Yingying

AU - Zhang, Zhibo

AU - Nordentoft, Malthe S.

AU - Lin, Wei

AU - Qian, Long

AU - Ouyang, Qi

AU - Jensen, Mogens H.

AU - Wei, Ping

PY - 2023/5/17

Y1 - 2023/5/17

N2 - Control of dynamical processes is vital for maintaining correct cell regulation and cell-fate decisions. Numerous regulatory networks show oscillatory behavior; however, our knowledge of how one oscillator behaves when stimulated by two or more external oscillatory signals is still missing. We explore this problem by constructing a synthetic oscillatory system in yeast and stimulate it with two external oscillatory signals. Letting model verification and prediction operate in a tight interplay with experimental observations, we find that stimulation with two external signals expands the plateau of entrainment and reduces the fluctuations of oscillations. Furthermore, by adjusting the phase differences of external signals, one can control the amplitude of oscillations, which is understood through the signal delay of the unperturbed oscillatory network. With this we reveal a direct amplitude dependency of downstream gene transcription. Taken together, these results suggest a new path to control oscillatory systems by coupled oscillator cooperativity.

AB - Control of dynamical processes is vital for maintaining correct cell regulation and cell-fate decisions. Numerous regulatory networks show oscillatory behavior; however, our knowledge of how one oscillator behaves when stimulated by two or more external oscillatory signals is still missing. We explore this problem by constructing a synthetic oscillatory system in yeast and stimulate it with two external oscillatory signals. Letting model verification and prediction operate in a tight interplay with experimental observations, we find that stimulation with two external signals expands the plateau of entrainment and reduces the fluctuations of oscillations. Furthermore, by adjusting the phase differences of external signals, one can control the amplitude of oscillations, which is understood through the signal delay of the unperturbed oscillatory network. With this we reveal a direct amplitude dependency of downstream gene transcription. Taken together, these results suggest a new path to control oscillatory systems by coupled oscillator cooperativity.

KW - coupled oscillators, entrainment, phase modulation, biological oscillation, synthetic biology, Arnold tongues, chronobiology, NF-κB, signaling dynamics

U2 - 10.1016/j.cels.2023.04.001

DO - 10.1016/j.cels.2023.04.001

M3 - Journal article

C2 - 37201507

AN - SCOPUS:85158821592

VL - 14

SP - 382-391.e5

JO - Cell Systems

JF - Cell Systems

SN - 2405-4712

IS - 5

ER -

ID: 356890907

Niels Bohr Institute