Mechanical basis and topological routes to cell elimination

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mechanical basis and topological routes to cell elimination. / Monfared, Siavash; Ravichandran, Guruswami; Andrade, Jose; Doostmohammadi, Amin.

In: eLife, Vol. 12, 82435, 18.04.2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Monfared, S, Ravichandran, G, Andrade, J & Doostmohammadi, A 2023, 'Mechanical basis and topological routes to cell elimination', eLife, vol. 12, 82435. https://doi.org/10.7554/eLife.82435

APA

Monfared, S., Ravichandran, G., Andrade, J., & Doostmohammadi, A. (2023). Mechanical basis and topological routes to cell elimination. eLife, 12, [82435]. https://doi.org/10.7554/eLife.82435

Vancouver

Monfared S, Ravichandran G, Andrade J, Doostmohammadi A. Mechanical basis and topological routes to cell elimination. eLife. 2023 Apr 18;12. 82435. https://doi.org/10.7554/eLife.82435

Author

Monfared, Siavash ; Ravichandran, Guruswami ; Andrade, Jose ; Doostmohammadi, Amin. / Mechanical basis and topological routes to cell elimination. In: eLife. 2023 ; Vol. 12.

Bibtex

@article{54d92105bbf24c0286e7da36d6a01ec3,
title = "Mechanical basis and topological routes to cell elimination",
abstract = "Cell layers eliminate unwanted cells through the extrusion process, which underlines healthy versus flawed tissue behaviors. Although several biochemical pathways have been identified, the underlying mechanical basis including the forces involved in cellular extrusion remains largely unexplored. Utilizing a phase-field model of a three-dimensional cell layer, we study the interplay of cell extrusion with cell-cell and cell-substrate interactions in a flat monolayer. Independent tuning of cell-cell versus cell-substrate adhesion forces reveals that extrusion events can be distinctly linked to defects in nematic and hexatic orders associated with cellular arrangements. Specifically, we show that by increasing relative cell-cell adhesion forces the cell monolayer can switch between the collective tendency towards fivefold, hexatic, disclinations relative to half-integer, nematic, defects for extruding a cell. We unify our findings by accessing three-dimensional mechanical stress fields to show that an extrusion event acts as a mechanism to relieve localized stress concentration.",
keywords = "epithelial cells, cell extrusion, collective cell migration, defects in liquid crystals, mechanobiology, biophysics, Other, CONTACT INHIBITION, DEFECTS, DYNAMICS, ANISOTROPY, MIGRATION, DIVISION, STRESS, FORCE",
author = "Siavash Monfared and Guruswami Ravichandran and Jose Andrade and Amin Doostmohammadi",
year = "2023",
month = apr,
day = "18",
doi = "10.7554/eLife.82435",
language = "English",
volume = "12",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - Mechanical basis and topological routes to cell elimination

AU - Monfared, Siavash

AU - Ravichandran, Guruswami

AU - Andrade, Jose

AU - Doostmohammadi, Amin

PY - 2023/4/18

Y1 - 2023/4/18

N2 - Cell layers eliminate unwanted cells through the extrusion process, which underlines healthy versus flawed tissue behaviors. Although several biochemical pathways have been identified, the underlying mechanical basis including the forces involved in cellular extrusion remains largely unexplored. Utilizing a phase-field model of a three-dimensional cell layer, we study the interplay of cell extrusion with cell-cell and cell-substrate interactions in a flat monolayer. Independent tuning of cell-cell versus cell-substrate adhesion forces reveals that extrusion events can be distinctly linked to defects in nematic and hexatic orders associated with cellular arrangements. Specifically, we show that by increasing relative cell-cell adhesion forces the cell monolayer can switch between the collective tendency towards fivefold, hexatic, disclinations relative to half-integer, nematic, defects for extruding a cell. We unify our findings by accessing three-dimensional mechanical stress fields to show that an extrusion event acts as a mechanism to relieve localized stress concentration.

AB - Cell layers eliminate unwanted cells through the extrusion process, which underlines healthy versus flawed tissue behaviors. Although several biochemical pathways have been identified, the underlying mechanical basis including the forces involved in cellular extrusion remains largely unexplored. Utilizing a phase-field model of a three-dimensional cell layer, we study the interplay of cell extrusion with cell-cell and cell-substrate interactions in a flat monolayer. Independent tuning of cell-cell versus cell-substrate adhesion forces reveals that extrusion events can be distinctly linked to defects in nematic and hexatic orders associated with cellular arrangements. Specifically, we show that by increasing relative cell-cell adhesion forces the cell monolayer can switch between the collective tendency towards fivefold, hexatic, disclinations relative to half-integer, nematic, defects for extruding a cell. We unify our findings by accessing three-dimensional mechanical stress fields to show that an extrusion event acts as a mechanism to relieve localized stress concentration.

KW - epithelial cells

KW - cell extrusion

KW - collective cell migration

KW - defects in liquid crystals

KW - mechanobiology

KW - biophysics

KW - Other

KW - CONTACT INHIBITION

KW - DEFECTS

KW - DYNAMICS

KW - ANISOTROPY

KW - MIGRATION

KW - DIVISION

KW - STRESS

KW - FORCE

U2 - 10.7554/eLife.82435

DO - 10.7554/eLife.82435

M3 - Journal article

C2 - 37070647

VL - 12

JO - eLife

JF - eLife

SN - 2050-084X

M1 - 82435

ER -

ID: 346047952