Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure. / Libera, Valeria; Andreeva, Elena A.; Martel, Anne; Thureau, Aurelien; Longo, Marialucia; Petrillo, Caterina; Paciaroni, Alessandro; Schiro, Giorgio; Comez, Lucia.

In: Journal of Physical Chemistry Letters, Vol. 12, No. 33, 26.08.2021, p. 8096-8102.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Libera, V, Andreeva, EA, Martel, A, Thureau, A, Longo, M, Petrillo, C, Paciaroni, A, Schiro, G & Comez, L 2021, 'Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure', Journal of Physical Chemistry Letters, vol. 12, no. 33, pp. 8096-8102. https://doi.org/10.1021/acs.jpclett.1c01840

APA

Libera, V., Andreeva, E. A., Martel, A., Thureau, A., Longo, M., Petrillo, C., Paciaroni, A., Schiro, G., & Comez, L. (2021). Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure. Journal of Physical Chemistry Letters, 12(33), 8096-8102. https://doi.org/10.1021/acs.jpclett.1c01840

Vancouver

Libera V, Andreeva EA, Martel A, Thureau A, Longo M, Petrillo C et al. Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure. Journal of Physical Chemistry Letters. 2021 Aug 26;12(33):8096-8102. https://doi.org/10.1021/acs.jpclett.1c01840

Author

Libera, Valeria ; Andreeva, Elena A. ; Martel, Anne ; Thureau, Aurelien ; Longo, Marialucia ; Petrillo, Caterina ; Paciaroni, Alessandro ; Schiro, Giorgio ; Comez, Lucia. / Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure. In: Journal of Physical Chemistry Letters. 2021 ; Vol. 12, No. 33. pp. 8096-8102.

Bibtex

@article{971de10437ae43af85c9cd2b17cfa546,
title = "Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure",
abstract = "Nucleic acid sequences rich in guanines can organize into noncanonical DNA G-quadruplexes (G4s) of variable size. The design of small molecules stabilizing the structure of G4s is a rapidly growing area for the development of novel anticancer therapeutic strategies and bottom-up nanotechnologies. Among a multitude of binders, porphyrins are very attractive due to their light activation that can make them valuable conformational regulators of G4s. Here, a structure-based strategy, integrating complementary probes, is employed to study the interaction between TMPyP4 porphyrin and a 22-base human telomeric sequence (Tel22) before and after irradiation with blue light. Porphyrin binding is discovered to promote Tel22 dimerization, while light irradiation of the Tel22-TMPyP4 complex controls dimer fraction. Such a change in quaternary structure is found to be strictly correlated with modifications at the secondary structure level, thus providing an unprecedented link between the degree of dimerization and the underlying conformational changes in G4s.",
keywords = "TELOMERE G-QUADRUPLEX, CATIONIC PORPHYRINS, SEQUENCE, ABSORPTION, LIGAND, TMPYP4",
author = "Valeria Libera and Andreeva, {Elena A.} and Anne Martel and Aurelien Thureau and Marialucia Longo and Caterina Petrillo and Alessandro Paciaroni and Giorgio Schiro and Lucia Comez",
year = "2021",
month = aug,
day = "26",
doi = "10.1021/acs.jpclett.1c01840",
language = "English",
volume = "12",
pages = "8096--8102",
journal = "Journal of Physical Chemistry Letters",
issn = "1948-7185",
publisher = "American Chemical Society",
number = "33",

}

RIS

TY - JOUR

T1 - Porphyrin Binding and Irradiation Promote G-Quadruplex DNA Dimeric Structure

AU - Libera, Valeria

AU - Andreeva, Elena A.

AU - Martel, Anne

AU - Thureau, Aurelien

AU - Longo, Marialucia

AU - Petrillo, Caterina

AU - Paciaroni, Alessandro

AU - Schiro, Giorgio

AU - Comez, Lucia

PY - 2021/8/26

Y1 - 2021/8/26

N2 - Nucleic acid sequences rich in guanines can organize into noncanonical DNA G-quadruplexes (G4s) of variable size. The design of small molecules stabilizing the structure of G4s is a rapidly growing area for the development of novel anticancer therapeutic strategies and bottom-up nanotechnologies. Among a multitude of binders, porphyrins are very attractive due to their light activation that can make them valuable conformational regulators of G4s. Here, a structure-based strategy, integrating complementary probes, is employed to study the interaction between TMPyP4 porphyrin and a 22-base human telomeric sequence (Tel22) before and after irradiation with blue light. Porphyrin binding is discovered to promote Tel22 dimerization, while light irradiation of the Tel22-TMPyP4 complex controls dimer fraction. Such a change in quaternary structure is found to be strictly correlated with modifications at the secondary structure level, thus providing an unprecedented link between the degree of dimerization and the underlying conformational changes in G4s.

AB - Nucleic acid sequences rich in guanines can organize into noncanonical DNA G-quadruplexes (G4s) of variable size. The design of small molecules stabilizing the structure of G4s is a rapidly growing area for the development of novel anticancer therapeutic strategies and bottom-up nanotechnologies. Among a multitude of binders, porphyrins are very attractive due to their light activation that can make them valuable conformational regulators of G4s. Here, a structure-based strategy, integrating complementary probes, is employed to study the interaction between TMPyP4 porphyrin and a 22-base human telomeric sequence (Tel22) before and after irradiation with blue light. Porphyrin binding is discovered to promote Tel22 dimerization, while light irradiation of the Tel22-TMPyP4 complex controls dimer fraction. Such a change in quaternary structure is found to be strictly correlated with modifications at the secondary structure level, thus providing an unprecedented link between the degree of dimerization and the underlying conformational changes in G4s.

KW - TELOMERE G-QUADRUPLEX

KW - CATIONIC PORPHYRINS

KW - SEQUENCE

KW - ABSORPTION

KW - LIGAND

KW - TMPYP4

U2 - 10.1021/acs.jpclett.1c01840

DO - 10.1021/acs.jpclett.1c01840

M3 - Journal article

C2 - 34406777

VL - 12

SP - 8096

EP - 8102

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

SN - 1948-7185

IS - 33

ER -

ID: 279626485