Unidirectional polymerization leading to homochirality in the RNA world

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Unidirectional polymerization leading to homochirality in the RNA world. / Nilsson, M.; Brandenburg, A.; Andersen, A. C.; Höfner, S.

In: International Journal of Astrobiology, Vol. 4, No. 3-4, 01.01.2005, p. 233-239.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nilsson, M, Brandenburg, A, Andersen, AC & Höfner, S 2005, 'Unidirectional polymerization leading to homochirality in the RNA world', International Journal of Astrobiology, vol. 4, no. 3-4, pp. 233-239. https://doi.org/10.1017/S1473550405002752

APA

Nilsson, M., Brandenburg, A., Andersen, A. C., & Höfner, S. (2005). Unidirectional polymerization leading to homochirality in the RNA world. International Journal of Astrobiology, 4(3-4), 233-239. https://doi.org/10.1017/S1473550405002752

Vancouver

Nilsson M, Brandenburg A, Andersen AC, Höfner S. Unidirectional polymerization leading to homochirality in the RNA world. International Journal of Astrobiology. 2005 Jan 1;4(3-4):233-239. https://doi.org/10.1017/S1473550405002752

Author

Nilsson, M. ; Brandenburg, A. ; Andersen, A. C. ; Höfner, S. / Unidirectional polymerization leading to homochirality in the RNA world. In: International Journal of Astrobiology. 2005 ; Vol. 4, No. 3-4. pp. 233-239.

Bibtex

@article{249b466c87a34eaca8f9d64175ae0dc9,
title = "Unidirectional polymerization leading to homochirality in the RNA world",
abstract = "The differences between unidirectional and bidirectional polymerization are considered. The unidirectional case is discussed in the framework of the RNA world. Similar to earlier models of this type, where polymerization was assumed to proceed in a bidirectional fashion (presumed to be relevant to peptide nucleic acids), left- and right-handed monomers are produced via an autocatalysis from an achiral substrate. The details of the bifurcation from a racemic solution to a homochiral state of either handedness is shown to be remarkably independent of whether the polymerization is unidirectional or bidirectional. Slightly larger differences are seen when dissociation is allowed and the dissociation fragments are recycled into the achiral substrate.",
keywords = "enantiomeric cross-inhibition, origin of homochirality, RNA and DNA polymerization",
author = "M. Nilsson and A. Brandenburg and Andersen, {A. C.} and S. H{\"o}fner",
year = "2005",
month = jan,
day = "1",
doi = "10.1017/S1473550405002752",
language = "English",
volume = "4",
pages = "233--239",
journal = "International Journal of Astrobiology",
issn = "1473-5504",
publisher = "Cambridge University Press",
number = "3-4",

}

RIS

TY - JOUR

T1 - Unidirectional polymerization leading to homochirality in the RNA world

AU - Nilsson, M.

AU - Brandenburg, A.

AU - Andersen, A. C.

AU - Höfner, S.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - The differences between unidirectional and bidirectional polymerization are considered. The unidirectional case is discussed in the framework of the RNA world. Similar to earlier models of this type, where polymerization was assumed to proceed in a bidirectional fashion (presumed to be relevant to peptide nucleic acids), left- and right-handed monomers are produced via an autocatalysis from an achiral substrate. The details of the bifurcation from a racemic solution to a homochiral state of either handedness is shown to be remarkably independent of whether the polymerization is unidirectional or bidirectional. Slightly larger differences are seen when dissociation is allowed and the dissociation fragments are recycled into the achiral substrate.

AB - The differences between unidirectional and bidirectional polymerization are considered. The unidirectional case is discussed in the framework of the RNA world. Similar to earlier models of this type, where polymerization was assumed to proceed in a bidirectional fashion (presumed to be relevant to peptide nucleic acids), left- and right-handed monomers are produced via an autocatalysis from an achiral substrate. The details of the bifurcation from a racemic solution to a homochiral state of either handedness is shown to be remarkably independent of whether the polymerization is unidirectional or bidirectional. Slightly larger differences are seen when dissociation is allowed and the dissociation fragments are recycled into the achiral substrate.

KW - enantiomeric cross-inhibition

KW - origin of homochirality

KW - RNA and DNA polymerization

UR - http://www.scopus.com/inward/record.url?scp=46749153114&partnerID=8YFLogxK

U2 - 10.1017/S1473550405002752

DO - 10.1017/S1473550405002752

M3 - Journal article

AN - SCOPUS:46749153114

VL - 4

SP - 233

EP - 239

JO - International Journal of Astrobiology

JF - International Journal of Astrobiology

SN - 1473-5504

IS - 3-4

ER -

ID: 208855472