Model to Link Cell Shape and Polarity with Organogenesis

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Model to Link Cell Shape and Polarity with Organogenesis. / Nielsen, Bjarke Frost; Nissen, Silas Boye; Sneppen, Kim; Mathiesen, Joachim; Trusina, Ala.

I: iScience, Bind 23, Nr. 2, 100830, 10.01.2020, s. 1-10.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nielsen, BF, Nissen, SB, Sneppen, K, Mathiesen, J & Trusina, A 2020, 'Model to Link Cell Shape and Polarity with Organogenesis', iScience, bind 23, nr. 2, 100830, s. 1-10. https://doi.org/10.1016/j.isci.2020.100830

APA

Nielsen, B. F., Nissen, S. B., Sneppen, K., Mathiesen, J., & Trusina, A. (2020). Model to Link Cell Shape and Polarity with Organogenesis. iScience, 23(2), 1-10. [100830]. https://doi.org/10.1016/j.isci.2020.100830

Vancouver

Nielsen BF, Nissen SB, Sneppen K, Mathiesen J, Trusina A. Model to Link Cell Shape and Polarity with Organogenesis. iScience. 2020 jan. 10;23(2):1-10. 100830. https://doi.org/10.1016/j.isci.2020.100830

Author

Nielsen, Bjarke Frost ; Nissen, Silas Boye ; Sneppen, Kim ; Mathiesen, Joachim ; Trusina, Ala. / Model to Link Cell Shape and Polarity with Organogenesis. I: iScience. 2020 ; Bind 23, Nr. 2. s. 1-10.

Bibtex

@article{54d685b604174011a3eeddb7e72bcb1f,
title = "Model to Link Cell Shape and Polarity with Organogenesis",
abstract = "How do flat sheets of cells form gut and neural tubes? Across systems, several mechanisms are at play: cells wedge, form actomyosin cables, or intercalate. As a result, the cell sheet bends, and the tube elongates. It is unclear to what extent each mechanism can drive tube formation on its own. To address this question, we computationally probe if one mechanism, either cell wedging or intercalation, may suffice for the entire sheet-to-tube transition. Using a physical model with epithelial cells represented by polarized point particles, we show that either cell intercalation or wedging alone can be sufficient and that each can both bend the sheet and extend the tube. When working in parallel, the two mechanisms increase the robustness of the tube formation. The successful simulations of the key features in Drosophila salivary gland budding, sea urchin gastrulation, and mammalian neurulation support the generality of our results.",
author = "Nielsen, {Bjarke Frost} and Nissen, {Silas Boye} and Kim Sneppen and Joachim Mathiesen and Ala Trusina",
year = "2020",
month = jan,
day = "10",
doi = "10.1016/j.isci.2020.100830",
language = "English",
volume = "23",
pages = "1--10",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Model to Link Cell Shape and Polarity with Organogenesis

AU - Nielsen, Bjarke Frost

AU - Nissen, Silas Boye

AU - Sneppen, Kim

AU - Mathiesen, Joachim

AU - Trusina, Ala

PY - 2020/1/10

Y1 - 2020/1/10

N2 - How do flat sheets of cells form gut and neural tubes? Across systems, several mechanisms are at play: cells wedge, form actomyosin cables, or intercalate. As a result, the cell sheet bends, and the tube elongates. It is unclear to what extent each mechanism can drive tube formation on its own. To address this question, we computationally probe if one mechanism, either cell wedging or intercalation, may suffice for the entire sheet-to-tube transition. Using a physical model with epithelial cells represented by polarized point particles, we show that either cell intercalation or wedging alone can be sufficient and that each can both bend the sheet and extend the tube. When working in parallel, the two mechanisms increase the robustness of the tube formation. The successful simulations of the key features in Drosophila salivary gland budding, sea urchin gastrulation, and mammalian neurulation support the generality of our results.

AB - How do flat sheets of cells form gut and neural tubes? Across systems, several mechanisms are at play: cells wedge, form actomyosin cables, or intercalate. As a result, the cell sheet bends, and the tube elongates. It is unclear to what extent each mechanism can drive tube formation on its own. To address this question, we computationally probe if one mechanism, either cell wedging or intercalation, may suffice for the entire sheet-to-tube transition. Using a physical model with epithelial cells represented by polarized point particles, we show that either cell intercalation or wedging alone can be sufficient and that each can both bend the sheet and extend the tube. When working in parallel, the two mechanisms increase the robustness of the tube formation. The successful simulations of the key features in Drosophila salivary gland budding, sea urchin gastrulation, and mammalian neurulation support the generality of our results.

U2 - 10.1016/j.isci.2020.100830

DO - 10.1016/j.isci.2020.100830

M3 - Journal article

C2 - 31986479

VL - 23

SP - 1

EP - 10

JO - iScience

JF - iScience

SN - 2589-0042

IS - 2

M1 - 100830

ER -

ID: 234703651