Pancreatic alpha and beta cells are globally phase-locked

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Standard

Pancreatic alpha and beta cells are globally phase-locked. / Ren, Huixia; Li, Yanjun; Han, Chengsheng; Yu, Yi; Shi, Bowen; Peng, Xiaohong; Wu, Shufang; Yang, Xiaojing; Kim, Sneppen; Chen, Liangyi; Tang, Chao; Zhang, Tianming.

I: Nature Communications, Bind 13, Nr. 1, 3721, 28.06.2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ren, H, Li, Y, Han, C, Yu, Y, Shi, B, Peng, X, Wu, S, Yang, X, Kim, S, Chen, L, Tang, C & Zhang, T 2022, 'Pancreatic alpha and beta cells are globally phase-locked', Nature Communications, bind 13, nr. 1, 3721. https://doi.org/10.1038/s41467-022-31373-6

APA

Ren, H., Li, Y., Han, C., Yu, Y., Shi, B., Peng, X., Wu, S., Yang, X., Kim, S., Chen, L., Tang, C., & Zhang, T. (2022). Pancreatic alpha and beta cells are globally phase-locked. Nature Communications, 13(1), [3721]. https://doi.org/10.1038/s41467-022-31373-6

Vancouver

Ren H, Li Y, Han C, Yu Y, Shi B, Peng X o.a. Pancreatic alpha and beta cells are globally phase-locked. Nature Communications. 2022 jun. 28;13(1). 3721. https://doi.org/10.1038/s41467-022-31373-6

Author

Ren, Huixia ; Li, Yanjun ; Han, Chengsheng ; Yu, Yi ; Shi, Bowen ; Peng, Xiaohong ; Wu, Shufang ; Yang, Xiaojing ; Kim, Sneppen ; Chen, Liangyi ; Tang, Chao ; Zhang, Tianming. / Pancreatic alpha and beta cells are globally phase-locked. I: Nature Communications. 2022 ; Bind 13, Nr. 1.

Bibtex

@article{8e68f6972f584e2792294ffd6e066dde,
title = "Pancreatic alpha and beta cells are globally phase-locked",
abstract = "The Ca2+ modulated pulsatile glucagon and insulin secretions by pancreatic alpha and beta cells play a crucial role in glucose homeostasis. However, how alpha and beta cells coordinate to produce various Ca2+ oscillation patterns is still elusive. Using a microfluidic device and transgenic mice, we recorded Ca2+ signals from islet alpha and beta cells, and observed heterogeneous Ca2+ oscillation patterns intrinsic to each islet. After a brief period of glucose stimulation, alpha and beta cells' oscillations were globally phase-locked. While the activation of alpha cells displayed a fixed time delay of similar to 20 s to that of beta cells, beta cells activated with a tunable period. Moreover, islet a cell number correlated with oscillation frequency. We built a mathematical model of islet Ca2+ oscillation incorporating paracrine interactions, which quantitatively agreed with the experimental data. Our study highlights the importance of cell-cell interaction in generating stable but tunable islet oscillation patterns.",
keywords = "PULSATILE INSULIN-SECRETION, GLUCAGON-SECRETION, CA2+ OSCILLATIONS, ELECTRICAL-ACTIVITY, MOUSE ISLETS, SUSTAINED OSCILLATIONS, PLASMA-INSULIN, BASAL INSULIN, CYCLIC-AMP, GLUCOSE",
author = "Huixia Ren and Yanjun Li and Chengsheng Han and Yi Yu and Bowen Shi and Xiaohong Peng and Shufang Wu and Xiaojing Yang and Sneppen Kim and Liangyi Chen and Chao Tang and Tianming Zhang",
year = "2022",
month = jun,
day = "28",
doi = "10.1038/s41467-022-31373-6",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Pancreatic alpha and beta cells are globally phase-locked

AU - Ren, Huixia

AU - Li, Yanjun

AU - Han, Chengsheng

AU - Yu, Yi

AU - Shi, Bowen

AU - Peng, Xiaohong

AU - Wu, Shufang

AU - Yang, Xiaojing

AU - Kim, Sneppen

AU - Chen, Liangyi

AU - Tang, Chao

AU - Zhang, Tianming

PY - 2022/6/28

Y1 - 2022/6/28

N2 - The Ca2+ modulated pulsatile glucagon and insulin secretions by pancreatic alpha and beta cells play a crucial role in glucose homeostasis. However, how alpha and beta cells coordinate to produce various Ca2+ oscillation patterns is still elusive. Using a microfluidic device and transgenic mice, we recorded Ca2+ signals from islet alpha and beta cells, and observed heterogeneous Ca2+ oscillation patterns intrinsic to each islet. After a brief period of glucose stimulation, alpha and beta cells' oscillations were globally phase-locked. While the activation of alpha cells displayed a fixed time delay of similar to 20 s to that of beta cells, beta cells activated with a tunable period. Moreover, islet a cell number correlated with oscillation frequency. We built a mathematical model of islet Ca2+ oscillation incorporating paracrine interactions, which quantitatively agreed with the experimental data. Our study highlights the importance of cell-cell interaction in generating stable but tunable islet oscillation patterns.

AB - The Ca2+ modulated pulsatile glucagon and insulin secretions by pancreatic alpha and beta cells play a crucial role in glucose homeostasis. However, how alpha and beta cells coordinate to produce various Ca2+ oscillation patterns is still elusive. Using a microfluidic device and transgenic mice, we recorded Ca2+ signals from islet alpha and beta cells, and observed heterogeneous Ca2+ oscillation patterns intrinsic to each islet. After a brief period of glucose stimulation, alpha and beta cells' oscillations were globally phase-locked. While the activation of alpha cells displayed a fixed time delay of similar to 20 s to that of beta cells, beta cells activated with a tunable period. Moreover, islet a cell number correlated with oscillation frequency. We built a mathematical model of islet Ca2+ oscillation incorporating paracrine interactions, which quantitatively agreed with the experimental data. Our study highlights the importance of cell-cell interaction in generating stable but tunable islet oscillation patterns.

KW - PULSATILE INSULIN-SECRETION

KW - GLUCAGON-SECRETION

KW - CA2+ OSCILLATIONS

KW - ELECTRICAL-ACTIVITY

KW - MOUSE ISLETS

KW - SUSTAINED OSCILLATIONS

KW - PLASMA-INSULIN

KW - BASAL INSULIN

KW - CYCLIC-AMP

KW - GLUCOSE

U2 - 10.1038/s41467-022-31373-6

DO - 10.1038/s41467-022-31373-6

M3 - Journal article

C2 - 35764654

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 3721

ER -

ID: 315261532