Protein Localization with Flexible DNA or RNA

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Standard

Protein Localization with Flexible DNA or RNA. / Bernhardsson, Per Johan Sebastian; Mitarai, Namiko; Sneppen, Kim.

I: PLoS.ONE., Bind 7, Nr. 2, 10.02.2012, s. e29218.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bernhardsson, PJS, Mitarai, N & Sneppen, K 2012, 'Protein Localization with Flexible DNA or RNA', PLoS.ONE., bind 7, nr. 2, s. e29218. https://doi.org/10.1371/journal.pone.0029218

APA

Bernhardsson, P. J. S., Mitarai, N., & Sneppen, K. (2012). Protein Localization with Flexible DNA or RNA. PLoS.ONE., 7(2), e29218. https://doi.org/10.1371/journal.pone.0029218

Vancouver

Bernhardsson PJS, Mitarai N, Sneppen K. Protein Localization with Flexible DNA or RNA. PLoS.ONE. 2012 feb. 10;7(2):e29218. https://doi.org/10.1371/journal.pone.0029218

Author

Bernhardsson, Per Johan Sebastian ; Mitarai, Namiko ; Sneppen, Kim. / Protein Localization with Flexible DNA or RNA. I: PLoS.ONE. 2012 ; Bind 7, Nr. 2. s. e29218.

Bibtex

@article{813dd27f465a43679a3dad458ebb24f6,
title = "Protein Localization with Flexible DNA or RNA",
abstract = "Localization of activity is ubiquitous in life, and also within sub-cellular compartments. Localization provides potential advantages as different proteins involved in the same cellular process may supplement each other on a fast timescale. It might also prevent proteins from being active in other regions of the cell. However localization is at odds with the spreading of unbound molecules by diffusion. We model the cost and gain for specific enzyme activity using localization strategies based on binding to sites of intermediate specificity. While such bindings in themselves decrease the activity of the protein on its target site, they may increase protein activity if stochastic motion allows the acting protein to touch both the intermediate binding site and the specific site simultaneously. We discuss this strategy in view of recent suggestions on long non-coding RNA as a facilitator of localized activity of chromatin modifiers.",
author = "Bernhardsson, {Per Johan Sebastian} and Namiko Mitarai and Kim Sneppen",
year = "2012",
month = feb,
day = "10",
doi = "10.1371/journal.pone.0029218",
language = "English",
volume = "7",
pages = "e29218",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Protein Localization with Flexible DNA or RNA

AU - Bernhardsson, Per Johan Sebastian

AU - Mitarai, Namiko

AU - Sneppen, Kim

PY - 2012/2/10

Y1 - 2012/2/10

N2 - Localization of activity is ubiquitous in life, and also within sub-cellular compartments. Localization provides potential advantages as different proteins involved in the same cellular process may supplement each other on a fast timescale. It might also prevent proteins from being active in other regions of the cell. However localization is at odds with the spreading of unbound molecules by diffusion. We model the cost and gain for specific enzyme activity using localization strategies based on binding to sites of intermediate specificity. While such bindings in themselves decrease the activity of the protein on its target site, they may increase protein activity if stochastic motion allows the acting protein to touch both the intermediate binding site and the specific site simultaneously. We discuss this strategy in view of recent suggestions on long non-coding RNA as a facilitator of localized activity of chromatin modifiers.

AB - Localization of activity is ubiquitous in life, and also within sub-cellular compartments. Localization provides potential advantages as different proteins involved in the same cellular process may supplement each other on a fast timescale. It might also prevent proteins from being active in other regions of the cell. However localization is at odds with the spreading of unbound molecules by diffusion. We model the cost and gain for specific enzyme activity using localization strategies based on binding to sites of intermediate specificity. While such bindings in themselves decrease the activity of the protein on its target site, they may increase protein activity if stochastic motion allows the acting protein to touch both the intermediate binding site and the specific site simultaneously. We discuss this strategy in view of recent suggestions on long non-coding RNA as a facilitator of localized activity of chromatin modifiers.

U2 - 10.1371/journal.pone.0029218

DO - 10.1371/journal.pone.0029218

M3 - Journal article

C2 - 22347995

VL - 7

SP - e29218

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 2

ER -

ID: 37540440