Translation attenuation mechanism in unfolded protein response

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.

TitelEvolution from Cellular to Social Scales
RedaktørerArne Skjeltorp, Arne Skjeltorp, Alexander Belushkin
Antal sider8
Publikationsdato1 dec. 2008
ISBN (Trykt)9781402087608
StatusUdgivet - 1 dec. 2008
NavnNATO Science for Peace and Security Series B: Physics and Biophysics

ID: 229440002