Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia: A molecular network approach

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia : A molecular network approach. / Gebicke-Haerter, Peter J.; Leonardi-Essmann, Fernando; Haerter, Jan O.; Rossner, Moritz J.; Falkai, Peter; Schmitt, Andrea; Raabe, Florian J.

In: Schizophrenia Research, Vol. 232, 01.06.2021, p. 1-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gebicke-Haerter, PJ, Leonardi-Essmann, F, Haerter, JO, Rossner, MJ, Falkai, P, Schmitt, A & Raabe, FJ 2021, 'Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia: A molecular network approach', Schizophrenia Research, vol. 232, pp. 1-10. https://doi.org/10.1016/j.schres.2021.04.014

APA

Gebicke-Haerter, P. J., Leonardi-Essmann, F., Haerter, J. O., Rossner, M. J., Falkai, P., Schmitt, A., & Raabe, F. J. (2021). Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia: A molecular network approach. Schizophrenia Research, 232, 1-10. https://doi.org/10.1016/j.schres.2021.04.014

Vancouver

Gebicke-Haerter PJ, Leonardi-Essmann F, Haerter JO, Rossner MJ, Falkai P, Schmitt A et al. Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia: A molecular network approach. Schizophrenia Research. 2021 Jun 1;232:1-10. https://doi.org/10.1016/j.schres.2021.04.014

Author

Gebicke-Haerter, Peter J. ; Leonardi-Essmann, Fernando ; Haerter, Jan O. ; Rossner, Moritz J. ; Falkai, Peter ; Schmitt, Andrea ; Raabe, Florian J. / Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia : A molecular network approach. In: Schizophrenia Research. 2021 ; Vol. 232. pp. 1-10.

Bibtex

@article{e015141acfd3495f9d3eec7c85bdbd35,
title = "Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia: A molecular network approach",
abstract = "The closely connected anterior cingulate cortex (ACC) and superior temporal cortex (STC) are important for higher cognitive functions. Both brain regions are disturbed in schizophrenia, i.e., functional and structural alterations have been reported. This postmortem investigation in brains from patients with schizophrenia and controls compared gene expression in the left ACC and left STC. Most differentially expressed genes were unique to each brain region, but some clusters of genes were equally dysregulated in both, giving rise to a more general disease-specific pattern of gene regulation. The data was used to construct a molecular network of the genes identically expressed in both regions as primary nodes and the metabolically connected genes as secondary nodes. The network analysis identified downregulated clusters of immune-associated gene products and upregulated clusters belonging to the ubiquitin-proteasome system. These findings could help to identify new potential therapeutic targets for future approaches. (c) 2021 Elsevier B.V. All rights reserved.",
keywords = "Postmortem, Schizophrenia, Gene expression, Anterior cingulate cortex, Molecular networks, PREFRONTAL CORTEX, MICROGLIAL ACTIVATION, BRAIN, EXPRESSION, PROTEIN, METAANALYSIS, RISK, MIND, RISPERIDONE, UBIQUITIN",
author = "Gebicke-Haerter, {Peter J.} and Fernando Leonardi-Essmann and Haerter, {Jan O.} and Rossner, {Moritz J.} and Peter Falkai and Andrea Schmitt and Raabe, {Florian J.}",
year = "2021",
month = jun,
day = "1",
doi = "10.1016/j.schres.2021.04.014",
language = "English",
volume = "232",
pages = "1--10",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Differential gene regulation in the anterior cingulate cortex and superior temporal cortex in schizophrenia

T2 - A molecular network approach

AU - Gebicke-Haerter, Peter J.

AU - Leonardi-Essmann, Fernando

AU - Haerter, Jan O.

AU - Rossner, Moritz J.

AU - Falkai, Peter

AU - Schmitt, Andrea

AU - Raabe, Florian J.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - The closely connected anterior cingulate cortex (ACC) and superior temporal cortex (STC) are important for higher cognitive functions. Both brain regions are disturbed in schizophrenia, i.e., functional and structural alterations have been reported. This postmortem investigation in brains from patients with schizophrenia and controls compared gene expression in the left ACC and left STC. Most differentially expressed genes were unique to each brain region, but some clusters of genes were equally dysregulated in both, giving rise to a more general disease-specific pattern of gene regulation. The data was used to construct a molecular network of the genes identically expressed in both regions as primary nodes and the metabolically connected genes as secondary nodes. The network analysis identified downregulated clusters of immune-associated gene products and upregulated clusters belonging to the ubiquitin-proteasome system. These findings could help to identify new potential therapeutic targets for future approaches. (c) 2021 Elsevier B.V. All rights reserved.

AB - The closely connected anterior cingulate cortex (ACC) and superior temporal cortex (STC) are important for higher cognitive functions. Both brain regions are disturbed in schizophrenia, i.e., functional and structural alterations have been reported. This postmortem investigation in brains from patients with schizophrenia and controls compared gene expression in the left ACC and left STC. Most differentially expressed genes were unique to each brain region, but some clusters of genes were equally dysregulated in both, giving rise to a more general disease-specific pattern of gene regulation. The data was used to construct a molecular network of the genes identically expressed in both regions as primary nodes and the metabolically connected genes as secondary nodes. The network analysis identified downregulated clusters of immune-associated gene products and upregulated clusters belonging to the ubiquitin-proteasome system. These findings could help to identify new potential therapeutic targets for future approaches. (c) 2021 Elsevier B.V. All rights reserved.

KW - Postmortem

KW - Schizophrenia

KW - Gene expression

KW - Anterior cingulate cortex

KW - Molecular networks

KW - PREFRONTAL CORTEX

KW - MICROGLIAL ACTIVATION

KW - BRAIN

KW - EXPRESSION

KW - PROTEIN

KW - METAANALYSIS

KW - RISK

KW - MIND

KW - RISPERIDONE

KW - UBIQUITIN

U2 - 10.1016/j.schres.2021.04.014

DO - 10.1016/j.schres.2021.04.014

M3 - Journal article

C2 - 34004381

VL - 232

SP - 1

EP - 10

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -

ID: 276380389