TY - JOUR

T1 - Active matter in a viscoelastic environment

AU - Plan, Emmanuel L. C. Vi M.

AU - Yeomans, Julia M.

AU - Doostmohammadi, Amin

PY - 2020/2/24

Y1 - 2020/2/24

N2 - Active matter systems such as eukaryotic cells and bacteria continuously transform chemical energy to motion. Hence living systems exert active stresses on the complex environments in which they reside. One recurring aspect of this complexity is the viscoelasticity of the medium surrounding living systems: Bacteria secrete their own viscoelastic extracellular matrix, and cells constantly deform, proliferate, and self-propel within viscoelastic networks of collagen. It is therefore imperative to understand how active matter modifies, and gets modified by, viscoelastic fluids. Here we present a two-phase model of active nematic matter that dynamically interacts with a passive viscoelastic polymeric phase and perform numerical simulations in two dimensions to illustrate its applicability. Motivated by recent experiments we first study the suppression of cell division by a viscoelastic medium surrounding the cell. We further show that the self-propulsion of a model keratocyte cell is modified by the polymer relaxation of the surrounding viscoelastic fluid in a nonuniform manner and find that increasing polymer viscosity effectively suppresses the cell motility. Last, we explore the hampering impact of the viscoelastic medium on the generic hydrodynamic instabilities of active nematics by simulating the dynamics of an active stripe within a polymeric fluid. The model presented here can provide a framework for investigating more complex dynamics such as the interaction of multicellular growing systems with viscoelastic environments.

AB - Active matter systems such as eukaryotic cells and bacteria continuously transform chemical energy to motion. Hence living systems exert active stresses on the complex environments in which they reside. One recurring aspect of this complexity is the viscoelasticity of the medium surrounding living systems: Bacteria secrete their own viscoelastic extracellular matrix, and cells constantly deform, proliferate, and self-propel within viscoelastic networks of collagen. It is therefore imperative to understand how active matter modifies, and gets modified by, viscoelastic fluids. Here we present a two-phase model of active nematic matter that dynamically interacts with a passive viscoelastic polymeric phase and perform numerical simulations in two dimensions to illustrate its applicability. Motivated by recent experiments we first study the suppression of cell division by a viscoelastic medium surrounding the cell. We further show that the self-propulsion of a model keratocyte cell is modified by the polymer relaxation of the surrounding viscoelastic fluid in a nonuniform manner and find that increasing polymer viscosity effectively suppresses the cell motility. Last, we explore the hampering impact of the viscoelastic medium on the generic hydrodynamic instabilities of active nematics by simulating the dynamics of an active stripe within a polymeric fluid. The model presented here can provide a framework for investigating more complex dynamics such as the interaction of multicellular growing systems with viscoelastic environments.

KW - DYNAMICS

KW - ELASTICITY

KW - STRESS

U2 - 10.1103/PhysRevFluids.5.023102

DO - 10.1103/PhysRevFluids.5.023102

M3 - Journal article

VL - 5

JO - Physical Review Fluids

JF - Physical Review Fluids

SN - 2469-9918

IS - 2

M1 - 023102

ER -