Synthesis of enantiopure 3-substituted morpholines
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Synthesis of enantiopure 3-substituted morpholines. / Bornholdt, Jan; Felding, Jakob; Kristensen, Jesper Langgaard.
I: Journal of Organic Chemistry, Bind 75, Nr. 21, 2010, s. 7454-7457.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Synthesis of enantiopure 3-substituted morpholines
AU - Bornholdt, Jan
AU - Felding, Jakob
AU - Kristensen, Jesper Langgaard
PY - 2010
Y1 - 2010
N2 - Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.
AB - Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1021/jo101339g
DO - 10.1021/jo101339g
M3 - Journal article
C2 - 20879782
VL - 75
SP - 7454
EP - 7457
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 21
ER -
ID: 22796243