Synthesis of enantiopure 3-substituted morpholines
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Enantiopure 3-substituted morpholines were assembled through ring-opening of a N-2-benzothiazolesulfonyl (Bts) activated aziridine with organocuprates followed by a ring annulation reaction with a vinylsulfonium salt under microwave conditions. Deprotection of the N-Bts group proceeds under very mild conditions with 2-mercaptoacetic acid and LiOH at rt.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Organic Chemistry |
Vol/bind | 75 |
Udgave nummer | 21 |
Sider (fra-til) | 7454-7457 |
ISSN | 0022-3263 |
DOI | |
Status | Udgivet - 2010 |
- Det tidligere Farmaceutiske Fakultet
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ID: 22796243