Unidirectional polymerization leading to homochirality in the RNA world
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Unidirectional polymerization leading to homochirality in the RNA world. / Nilsson, M.; Brandenburg, A.; Andersen, A. C.; Höfner, S.
I: International Journal of Astrobiology, Bind 4, Nr. 3-4, 01.01.2005, s. 233-239.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Unidirectional polymerization leading to homochirality in the RNA world
AU - Nilsson, M.
AU - Brandenburg, A.
AU - Andersen, A. C.
AU - Höfner, S.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - The differences between unidirectional and bidirectional polymerization are considered. The unidirectional case is discussed in the framework of the RNA world. Similar to earlier models of this type, where polymerization was assumed to proceed in a bidirectional fashion (presumed to be relevant to peptide nucleic acids), left- and right-handed monomers are produced via an autocatalysis from an achiral substrate. The details of the bifurcation from a racemic solution to a homochiral state of either handedness is shown to be remarkably independent of whether the polymerization is unidirectional or bidirectional. Slightly larger differences are seen when dissociation is allowed and the dissociation fragments are recycled into the achiral substrate.
AB - The differences between unidirectional and bidirectional polymerization are considered. The unidirectional case is discussed in the framework of the RNA world. Similar to earlier models of this type, where polymerization was assumed to proceed in a bidirectional fashion (presumed to be relevant to peptide nucleic acids), left- and right-handed monomers are produced via an autocatalysis from an achiral substrate. The details of the bifurcation from a racemic solution to a homochiral state of either handedness is shown to be remarkably independent of whether the polymerization is unidirectional or bidirectional. Slightly larger differences are seen when dissociation is allowed and the dissociation fragments are recycled into the achiral substrate.
KW - enantiomeric cross-inhibition
KW - origin of homochirality
KW - RNA and DNA polymerization
UR - http://www.scopus.com/inward/record.url?scp=46749153114&partnerID=8YFLogxK
U2 - 10.1017/S1473550405002752
DO - 10.1017/S1473550405002752
M3 - Journal article
AN - SCOPUS:46749153114
VL - 4
SP - 233
EP - 239
JO - International Journal of Astrobiology
JF - International Journal of Astrobiology
SN - 1473-5504
IS - 3-4
ER -
ID: 208855472