Cortical signatures of precision grip force control in children, adolescents and adults
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Cortical signatures of precision grip force control in children, adolescents and adults. / Beck, Mikkel Malling; Spedden, Meaghan Elizabeth; Dietz, Martin; Karabanov, Anke Ninija; Christensen, Mark Schram; Lundbye-Jensen, Jesper.
I: eLife, Bind 10, e61018, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cortical signatures of precision grip force control in children, adolescents and adults
AU - Beck, Mikkel Malling
AU - Spedden, Meaghan Elizabeth
AU - Dietz, Martin
AU - Karabanov, Anke Ninija
AU - Christensen, Mark Schram
AU - Lundbye-Jensen, Jesper
N1 - CURIS 2021 NEXS 215
PY - 2021
Y1 - 2021
N2 - Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous control we analyzed electroencephalographic data from 88 individuals (range 8-30y) performing a visually-guided precision grip task using Dynamic Causal Modelling (DCM) and Parametric Empirical Bayes (PEB). Our results demonstrate that bidirectional coupling in a canonical 'grasping network' is associated with precision grip performance across age groups. We further demonstrate greater backward coupling from higher-order to lower-order sensorimotor regions from late adolescence in addition to differential associations between connectivity strength in a premotor-prefrontal network and motor performance for different age groups. We interpret these findings as reflecting greater use of top-down and executive control processes with development. These results expand our understanding of the cortical mechanisms that support dexterous abilities through development.
AB - Human dexterous motor control improves from childhood to adulthood, but little is known about the changes in cortico-cortical communication that support such ontogenetic refinement of motor skills. To investigate age-related differences in connectivity between cortical regions involved in dexterous control we analyzed electroencephalographic data from 88 individuals (range 8-30y) performing a visually-guided precision grip task using Dynamic Causal Modelling (DCM) and Parametric Empirical Bayes (PEB). Our results demonstrate that bidirectional coupling in a canonical 'grasping network' is associated with precision grip performance across age groups. We further demonstrate greater backward coupling from higher-order to lower-order sensorimotor regions from late adolescence in addition to differential associations between connectivity strength in a premotor-prefrontal network and motor performance for different age groups. We interpret these findings as reflecting greater use of top-down and executive control processes with development. These results expand our understanding of the cortical mechanisms that support dexterous abilities through development.
KW - Faculty of Science
KW - Development
KW - Motor control
KW - Electroencephalography
KW - Effective connectivity
U2 - 10.7554/eLife.61018
DO - 10.7554/eLife.61018
M3 - Journal article
C2 - 34121656
VL - 10
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e61018
ER -
ID: 272062114