Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity - A PREVIEW randomized clinical trial
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Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity - A PREVIEW randomized clinical trial. / Dorenbos, Elke; Drummen, Mathijs; Adam, Tanja; Rijks, Jesse; Winkens, Bjorn; Martínez, J Alfredo; Navas-Carretero, Santiago; Stratton, Gareth; Swindell, Nils; Stouthart, Pauline; Mackintosh, Kelly; McNarry, Melitta; Tremblay, Angelo; Fogelholm, Mikael; Raben, Anne; Westerterp-Plantenga, Margriet; Vreugdenhil, Anita.
I: Pediatric Obesity, Bind 16, Nr. 1, e12702, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity - A PREVIEW randomized clinical trial
AU - Dorenbos, Elke
AU - Drummen, Mathijs
AU - Adam, Tanja
AU - Rijks, Jesse
AU - Winkens, Bjorn
AU - Martínez, J Alfredo
AU - Navas-Carretero, Santiago
AU - Stratton, Gareth
AU - Swindell, Nils
AU - Stouthart, Pauline
AU - Mackintosh, Kelly
AU - McNarry, Melitta
AU - Tremblay, Angelo
AU - Fogelholm, Mikael
AU - Raben, Anne
AU - Westerterp-Plantenga, Margriet
AU - Vreugdenhil, Anita
N1 - © 2020 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
PY - 2021
Y1 - 2021
N2 - Background: Pubertal insulin resistance (IR) is associated with increased risk of type 2 diabetes mellitus development in adolescents with overweight/obesity.Objectives: The PREVIEW study was a randomized parallel trial assessing the change in IR, analyzed by Homeostatic Model Assessment of IR (HOMA-IR), at 2 years after randomization to a high protein vs a moderate protein diet in adolescents with overweight/obesity. It was hypothesized that a high protein/low glycaemic index diet would be superior in reducing IR compared to a medium protein/medium GI diet, in insulin resistant adolescents with overweight or obesity.Methods: Adolescents with overweight/obesity and IR from the Netherlands, United Kingdom and Spain were randomized into a moderate protein/moderate GI (15/55/30En% protein/carbohydrate/fat, GI ≥ 56) or high protein/low GI (25/45/30En% protein/carbohydrate/fat, GI < 50) diet. Anthropometric and cardiometabolic parameters, puberty, dietary intake and physical activity (PA) were measured and effects on HOMA-IR were analyzed.Results: 126 adolescents were included in this study (13.6 ± 2.2 years, BMI z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28, HP n = 68, MP n = 58). At 2 years, changes in protein intake were not significantly different between timepoints or intervention groups and no effects of the intervention on IR were observed. The retention rate was 39%, while no compliance to the diets was observed.Conclusions: The PREVIEW study observed no effect of a high protein/low GI diet on IR in adolescents with overweight/obesity and IR because of lack of feasibility, due to insufficient retention and dietary compliance after 2 years.
AB - Background: Pubertal insulin resistance (IR) is associated with increased risk of type 2 diabetes mellitus development in adolescents with overweight/obesity.Objectives: The PREVIEW study was a randomized parallel trial assessing the change in IR, analyzed by Homeostatic Model Assessment of IR (HOMA-IR), at 2 years after randomization to a high protein vs a moderate protein diet in adolescents with overweight/obesity. It was hypothesized that a high protein/low glycaemic index diet would be superior in reducing IR compared to a medium protein/medium GI diet, in insulin resistant adolescents with overweight or obesity.Methods: Adolescents with overweight/obesity and IR from the Netherlands, United Kingdom and Spain were randomized into a moderate protein/moderate GI (15/55/30En% protein/carbohydrate/fat, GI ≥ 56) or high protein/low GI (25/45/30En% protein/carbohydrate/fat, GI < 50) diet. Anthropometric and cardiometabolic parameters, puberty, dietary intake and physical activity (PA) were measured and effects on HOMA-IR were analyzed.Results: 126 adolescents were included in this study (13.6 ± 2.2 years, BMI z-score 3.04 ± 0.66, HOMA-IR 3.48 ± 2.28, HP n = 68, MP n = 58). At 2 years, changes in protein intake were not significantly different between timepoints or intervention groups and no effects of the intervention on IR were observed. The retention rate was 39%, while no compliance to the diets was observed.Conclusions: The PREVIEW study observed no effect of a high protein/low GI diet on IR in adolescents with overweight/obesity and IR because of lack of feasibility, due to insufficient retention and dietary compliance after 2 years.
KW - Faculty of Science
KW - Dietary protein
KW - Glycaemic index
KW - Glycaemic load
KW - Physical activity
KW - Pubertal insulin resistance
U2 - 10.1111/ijpo.12702
DO - 10.1111/ijpo.12702
M3 - Journal article
C2 - 32681547
VL - 16
JO - Pediatric obesity
JF - Pediatric obesity
SN - 2047-6302
IS - 1
M1 - e12702
ER -
ID: 245230932