Effects of South African traditional medicine in animal models for depression
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Effects of South African traditional medicine in animal models for depression. / Pedersen, Mikael Egebjerg; Szewczyk, Bernadeta; Stachowicz, Katarzyna; Wieronska, Joanna; Andersen, Jacob; Stafford, Gary Ivan; van Staden, Johannes; Pilc, Andrzej; Jäger, Anna Katharina.
I: Journal of Ethnopharmacology, Bind 119, Nr. 3, 2008, s. 542-548.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Effects of South African traditional medicine in animal models for depression
AU - Pedersen, Mikael Egebjerg
AU - Szewczyk, Bernadeta
AU - Stachowicz, Katarzyna
AU - Wieronska, Joanna
AU - Andersen, Jacob
AU - Stafford, Gary Ivan
AU - van Staden, Johannes
AU - Pilc, Andrzej
AU - Jäger, Anna Katharina
N1 - Keywords: Dopamine transporter inhibitors Forced swim test Norepinephrine transporter inhibitors Serotonin transporter inhibitors South African medicinal plants Tail suspension test
PY - 2008
Y1 - 2008
N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The four South African medicinal plants Agapanthus campanulatus (AC), Boophone distica (BD), Mondia whitei (MW) and Xysmalobium undulatum (XU) are used in traditional medicine to treat depression. AIM: To evaluate the effect of ethanolic extracts of the plants in models for depression. MATERIALS AND METHODS: The extracts were screened for affinity for the serotonin transporter (SERT) in the [(3)H]-citalopram-binding assay. The inhibitory potency of the extracts towards the SERT, the noradrenalin transporter (NAT) and the dopamine transporter (DAT) were determined in a functional uptake inhibition assay. Antidepressant-like effects of the extracts were investigated using the tail suspension test (TST) and the forced swim test in both rats (rFST) and mice (mFST). RESULTS: All four plants showed affinity for SERT in the binding assay. AC and BD showed functional inhibition of SERT, NAT and DAT, MW affected SERT while XU showed no effect. BD showed significant effect in the TST and in the mFST/rFST, AC showed significant effect in mFST, MW showed significant effect in the rFST and XU showed significant effect in the mFST. CONCLUSION: In this study we have demonstrated the antidepressant activity of four South African medicinal plants in vitro and in vivo, supporting their rational use in traditional medicine.
AB - ETHNOPHARMACOLOGICAL RELEVANCE: The four South African medicinal plants Agapanthus campanulatus (AC), Boophone distica (BD), Mondia whitei (MW) and Xysmalobium undulatum (XU) are used in traditional medicine to treat depression. AIM: To evaluate the effect of ethanolic extracts of the plants in models for depression. MATERIALS AND METHODS: The extracts were screened for affinity for the serotonin transporter (SERT) in the [(3)H]-citalopram-binding assay. The inhibitory potency of the extracts towards the SERT, the noradrenalin transporter (NAT) and the dopamine transporter (DAT) were determined in a functional uptake inhibition assay. Antidepressant-like effects of the extracts were investigated using the tail suspension test (TST) and the forced swim test in both rats (rFST) and mice (mFST). RESULTS: All four plants showed affinity for SERT in the binding assay. AC and BD showed functional inhibition of SERT, NAT and DAT, MW affected SERT while XU showed no effect. BD showed significant effect in the TST and in the mFST/rFST, AC showed significant effect in mFST, MW showed significant effect in the rFST and XU showed significant effect in the mFST. CONCLUSION: In this study we have demonstrated the antidepressant activity of four South African medicinal plants in vitro and in vivo, supporting their rational use in traditional medicine.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1016/j.jep.2008.08.030
DO - 10.1016/j.jep.2008.08.030
M3 - Journal article
C2 - 18809486
VL - 119
SP - 542
EP - 548
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
SN - 0378-8741
IS - 3
ER -
ID: 8297463