Endocrine regulation of ion transport in the avian lower intestine
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Endocrine regulation of ion transport in the avian lower intestine. / Laverty, Gary; Elbrønd, Vibeke Sødring; Árnason, Sighvatur S.; Skadhauge, Erik.
I: General and Comparative Endocrinology, Bind 147, Nr. 1, 2006, s. 70-77.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Endocrine regulation of ion transport in the avian lower intestine
AU - Laverty, Gary
AU - Elbrønd, Vibeke Sødring
AU - Árnason, Sighvatur S.
AU - Skadhauge, Erik
PY - 2006
Y1 - 2006
N2 - The lower intestine (colon and coprodeum) of the domestic fowl maintains a very active, transporting epithelium, with a microvillus brush border, columnar epithelial cells, and a variety of transport systems. The colon of normal or high salt-acclimated hens expresses sodium-linked glucose and amino acid cotransporters, while the coprodeum is relatively inactive. Following acclimation to low salt diets, however, both colon and coprodeum shift to a pattern of high expression of electrogenic sodium channels, and the colonic cotransporter activity is simultaneously downregulated. These changes in the transport patterns seem to be regulated, at least in part, by aldosterone. Our recent work with this tissue has focused on whether aldosterone alone can account for the low salt pattern of transport. Other work has looked at the changes in morphology and in proportions of cell types that occur during chronic acclimation to high or low salt diets, and on a cAMP-activated chloride secretion pathway. Recent findings suggesting effects of other hormones on lower intestinal transport are also presented.
AB - The lower intestine (colon and coprodeum) of the domestic fowl maintains a very active, transporting epithelium, with a microvillus brush border, columnar epithelial cells, and a variety of transport systems. The colon of normal or high salt-acclimated hens expresses sodium-linked glucose and amino acid cotransporters, while the coprodeum is relatively inactive. Following acclimation to low salt diets, however, both colon and coprodeum shift to a pattern of high expression of electrogenic sodium channels, and the colonic cotransporter activity is simultaneously downregulated. These changes in the transport patterns seem to be regulated, at least in part, by aldosterone. Our recent work with this tissue has focused on whether aldosterone alone can account for the low salt pattern of transport. Other work has looked at the changes in morphology and in proportions of cell types that occur during chronic acclimation to high or low salt diets, and on a cAMP-activated chloride secretion pathway. Recent findings suggesting effects of other hormones on lower intestinal transport are also presented.
KW - Former LIFE faculty
KW - Aldosterone
KW - Low and high salt diets
KW - Hen lower intestine
KW - Arginine vasotocin
KW - Prolactin
KW - Ion transport
KW - Colon
KW - Coprodeum
KW - Avian intestine
U2 - 10.1016/j.ygcen.2006.01.008
DO - 10.1016/j.ygcen.2006.01.008
M3 - Journal article
C2 - 16494879
VL - 147
SP - 70
EP - 77
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
SN - 0016-6480
IS - 1
ER -
ID: 8009522