Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The synthesis of a series of derivatized flavylium cations was undertaken and the affinity to the benzodiazepine binding site of the GABA-A receptor evaluated. The observed high affinity for some derivatives (sub-muM range) was explained by an in vitro transformation of the flavylium cations into the corresponding trans-retrochalcones, components which are proposed to be the active species in this series.
Originalsprog | Engelsk |
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Tidsskrift | Bioorganic & Medicinal Chemistry Letters |
Vol/bind | 18 |
Udgave nummer | 17 |
Sider (fra-til) | 4864-4867 |
ISSN | 0960-894X |
DOI | |
Status | Udgivet - 2008 |
- Det tidligere Farmaceutiske Fakultet
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ID: 10161334