Galloylated proanthocyanidins from shea (Vitellaria paradoxa) meal have potent anthelmintic activity against Ascaris suum
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Galloylated proanthocyanidins from shea (Vitellaria paradoxa) meal have potent anthelmintic activity against Ascaris suum. / Ramsay, A; Williams, A R; Thamsborg, S M; Mueller-Harvey, I.
I: Phytochemistry, Bind 122, 02.2016, s. 146-153.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Galloylated proanthocyanidins from shea (Vitellaria paradoxa) meal have potent anthelmintic activity against Ascaris suum
AU - Ramsay, A
AU - Williams, A R
AU - Thamsborg, S M
AU - Mueller-Harvey, I
N1 - Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.
PY - 2016/2
Y1 - 2016/2
N2 - Proanthocyanidins (PA) from shea (Vitellaria paradoxa) meal were investigated by thiolytic degradation with benzyl mercaptan and the reaction products were analysed by high performance liquid chromatography-mass spectrometry. These PA were galloylated (≈40%), contained only B-type linkages and had a high proportion of prodelphinidins (>70%). The mean degree of polymerisation was 8 (i.e. average molecular size was 2384Da) and epigallocatechin gallate (EGCg) was the major flavan-3-ol subunit in PA. Shea meal also proved to be a potentially valuable source for extracting free flavan-3-ol-O-gallates, especially EGCg (575mg/kg meal), which is known for its health and anti-parasitic benefits. Proanthocyanidins were isolated and tested for bioactivity against Ascaris suum, which is an important parasite of pigs. Migration and motility tests revealed that these PA have potent activity against this parasitic nematode.
AB - Proanthocyanidins (PA) from shea (Vitellaria paradoxa) meal were investigated by thiolytic degradation with benzyl mercaptan and the reaction products were analysed by high performance liquid chromatography-mass spectrometry. These PA were galloylated (≈40%), contained only B-type linkages and had a high proportion of prodelphinidins (>70%). The mean degree of polymerisation was 8 (i.e. average molecular size was 2384Da) and epigallocatechin gallate (EGCg) was the major flavan-3-ol subunit in PA. Shea meal also proved to be a potentially valuable source for extracting free flavan-3-ol-O-gallates, especially EGCg (575mg/kg meal), which is known for its health and anti-parasitic benefits. Proanthocyanidins were isolated and tested for bioactivity against Ascaris suum, which is an important parasite of pigs. Migration and motility tests revealed that these PA have potent activity against this parasitic nematode.
KW - Faculty of Health and Medical Sciences
KW - Vitellaria paradoxa
KW - Shea meal
KW - Thiolysis
KW - Proanthocyanidins
KW - Galloylated
KW - Ascaris suum
KW - Anthelmintic
KW - LC–MS
U2 - 10.1016/j.phytochem.2015.12.005
DO - 10.1016/j.phytochem.2015.12.005
M3 - Journal article
C2 - 26708339
VL - 122
SP - 146
EP - 153
JO - Phytochemistry
JF - Phytochemistry
SN - 0031-9422
ER -
ID: 161246944