Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration
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Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration. / Jørgensen, Anna Cecilia; Torstenson, Anette Seo.
I: Pharmaceutical Development and Technology, Bind 13, Nr. 3, 2008, s. 187-95.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration
AU - Jørgensen, Anna Cecilia
AU - Torstenson, Anette Seo
N1 - Keywords: Calorimetry, Differential Scanning; Diazepam; Drug Storage; Humidity; Hypnotics and Sedatives; Kinetics; Microscopy, Electron, Scanning; Particle Size; Solubility; Spectroscopy, Near-Infrared; Thermogravimetry; Water; X-Ray Diffraction
PY - 2008
Y1 - 2008
N2 - The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.
AB - The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1080/10837450801949384
DO - 10.1080/10837450801949384
M3 - Journal article
C2 - 18484487
VL - 13
SP - 187
EP - 195
JO - Pharmaceutical Development and Technology
JF - Pharmaceutical Development and Technology
SN - 1083-7450
IS - 3
ER -
ID: 9171914